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Titolo:
NEURODEGENERATION INDUCED BY REVERSED MICRODIALYSIS OF NMDA - A QUANTITATIVE MODEL FOR EXCITOTOXICITY IN-VIVO
Autore:
VANICKY I; MARSALA M; YAKSH TL;
Indirizzi:
SLOVAK ACAD SCI,INST NEUROBIOL,SOLTESOVEJ 4 KOSICE 04001 SLOVAKIA UNIV CALIF SAN DIEGO,ANESTHESIOL RES LAB LA JOLLA CA 92093
Titolo Testata:
Brain research
fascicolo: 2, volume: 789, anno: 1998,
pagine: 347 - 350
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; INTRAVENTRICULAR INFUSION; RAT HIPPOCAMPUS; IN-VIVO; ACID; CONSEQUENCES; GLUTAMATE; PROTECTS; RELEASE; LESIONS;
Keywords:
MICRODIALYSIS; EXCITOTOXICITY; N-METHYL-D-ASPARTATE; HISTOLOGY; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
I. Vanicky et al., "NEURODEGENERATION INDUCED BY REVERSED MICRODIALYSIS OF NMDA - A QUANTITATIVE MODEL FOR EXCITOTOXICITY IN-VIVO", Brain research, 789(2), 1998, pp. 347-350

Abstract

This study characterizes a quantifiable in vivo model of excitotoxicity. In halothane anesthetized rats, microdialysis probe was implanted into somatosensory cortex/striatum and perfused by various concentrations (1, 10, 50 and 100 mmol/l) of N-methyl-D-aspartate (NMDA) for 20 min. After 24 h, histological quantification confirmed that NMDA produced a concentration-dependent excitotoxic lesion. With 10 mmol/l NMDA, coadministration of magnesium reduced significantly, and 2-amino-5-phosphonovalerate blocked completely the development of excitotoxic injury. (C) 1998 Elsevier Science B.V.

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Documento generato il 07/07/20 alle ore 22:34:37