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Titolo:
EXPRESSION OF ARNT, ARNT2, HIF1-ALPHA, HIF2-ALPHA AND AH RECEPTOR MESSENGER-RNAS IN THE DEVELOPING MOUSE
Autore:
JAIN S; MALTEPE E; LU MM; SIMON C; BRADFIELD CA;
Indirizzi:
UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES,1400 UNIV AVE MADISON WI 53706 UNIV WISCONSIN,SCH MED,MCARDLE LAB CANC RES MADISON WI 53706 NORTHWESTERN UNIV,SCH MED,DEPT BIOL CHEM & MOL PHARMACOL EVANSTON IL 60208 UNIV CHICAGO,DEPT MOL GENET & CELL BIOL CHICAGO IL 60637
Titolo Testata:
Mechanisms of development
fascicolo: 1, volume: 73, anno: 1998,
pagine: 117 - 123
SICI:
0925-4773(1998)73:1<117:EOAAHH>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARYL-HYDROCARBON RECEPTOR; NUCLEAR TRANSLOCATOR; DEVELOPMENTAL EXPRESSION; TRANSCRIPTION FACTORS; 2 MEMBERS; CLONING; EMBRYO;
Keywords:
BASIC HELIX-LOOP-HELIX-PAS; PAS PROTEINS; BHLH-PAS; AH RECEPTOR; AH RECEPTOR NUCLEAR TRANSLOCATOR; ARNT; ARNT2; HYPOXIA INDUCIBLE FACTORS; HIF1-ALPHA; HIF2-ALPHA; PAS; HYPOXIA; XENOBIOTIC; EPAS1; MOP2; DIOXIN; TCDD; ENDOTHELIAL; HLF; HRF;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S. Jain et al., "EXPRESSION OF ARNT, ARNT2, HIF1-ALPHA, HIF2-ALPHA AND AH RECEPTOR MESSENGER-RNAS IN THE DEVELOPING MOUSE", Mechanisms of development, 73(1), 1998, pp. 117-123

Abstract

The basic helix-loop-helix-PAS (bHLH-PAS) protein ARNT is a dimeric partner of the Ah receptor (AHR) and hypoxia inducible factor 1 alpha (HIF1 alpha). These dimers mediate biological responses to xenobiotic exposure and low oxygen tension. The recent cloning of ARNT and HIF1 homologues (ARNT2 and HIF2 alpha) indicates that at least six distinct bHLH-PAS heterodimeric combinations can occur in response to a number of environmental stimuli. In an effort to understand the biological relevance of this combinatorial complexity, we characterized their relative expression at a number of developmental time points by parallel in situ hybridization of adjacent tissue sections. Our results reveal that in general there is limited redundancy in the expression of these six transcription factors and that each of these bHLH-PAS members displays a unique pattern of developmental expression emerging as early as embryonic day 9.5. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 21:46:51