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Titolo:
SYNTHESIS OF C-14-RADIOLABELED OLIGONUCLEOTIDES WITH A NOVEL PHOSPHORAMIDITE REAGENT
Autore:
GUZAEV A; BOYODE B; BALOW G; TIVEL KL; MANOHARAN M;
Indirizzi:
ISIS PHARMACEUT,DEPT MED CHEM,2280 FARADAY AVE CARLSBAD CA 92008 MORAVEK BIOCHEM INC BREA CA 92821
Titolo Testata:
Bioorganic & medicinal chemistry letters
fascicolo: 9, volume: 8, anno: 1998,
pagine: 1123 - 1126
SICI:
0960-894X(1998)8:9<1123:SOCOWA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTISENSE OLIGONUCLEOTIDES; LABELED OLIGONUCLEOTIDES; CHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
A. Guzaev et al., "SYNTHESIS OF C-14-RADIOLABELED OLIGONUCLEOTIDES WITH A NOVEL PHOSPHORAMIDITE REAGENT", Bioorganic & medicinal chemistry letters, 8(9), 1998, pp. 1123-1126

Abstract

A novel solid-phase synthesis of 5'-radiolabeled oligonucleotides is described. The labeling reaction is carried out by the phosphoramiditemethod with the aid of [4,6-di-C-14]-5'-dimethoxytritylthymidine building block 1. The feasibility of the method is demonstrated by preparation of 3'-phosphorylated dodecathymidylate phosphorothioate containing radiolabeled nucleoside at the 5'-terminus. (C) 1998 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 09:23:48