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Titolo:
ENHANCED RESPONSES OF THE CHORDA TYMPANI NERVE TO NONSUGAR SWEETENERSIN THE DIABETIC DB DB MOUSE/
Autore:
NINOMIYA Y; IMOTO T; YATABE A; KAWAMURA S; NAKASHIMA K; KATSUKAWA H;
Indirizzi:
ASAHI UNIV,SCH DENT,DEPT ORAL PHYSIOL GIFU 50102 JAPAN ASAHI UNIV,SCH DENT,DEPT ORAL PHYSIOL CHEM & PEDIAT DENT GIFU 50102 JAPAN TOTTORI UNIV,SCH MED,DEPT PHYSIOL YONAGO TOTTORI 683 JAPAN
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 5, volume: 43, anno: 1998,
pagine: 1324 - 1330
SICI:
0363-6119(1998)43:5<1324:EROTCT>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL RESPONSES; MICE;
Keywords:
GENETICALLY DIABETIC MICE; ENHANCED SWEET TASTE RESPONSES; GURMARIN-INSENSITIVE TASTE RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
Y. Ninomiya et al., "ENHANCED RESPONSES OF THE CHORDA TYMPANI NERVE TO NONSUGAR SWEETENERSIN THE DIABETIC DB DB MOUSE/", American journal of physiology. Regulatory, integrative and comparative physiology, 43(5), 1998, pp. 1324-1330

Abstract

Genetically diabetic db/db mice show greater neural and behavioral responses to sugars than lean control mice. The present study examined chorda tympani responses of db/db mice to nonsugar sweeteners and theirinhibition by a sweet response inhibitor, gurmarin. The results showed that responses to sucrose, saccharin, glycine, L-alanine, and D-tryptophan, but not to D-phenylalanine, were similar to 1.5 times greater in db/db mice than in control mice. Treatment of the tongue with gurmarin suppressed responses to these sweeteners in db/db and control mice, but the extent of suppression was considerably smaller in db/db mice. The magnitudes of gurmarin-sensitive components of the response to sweeteners in db/db mice were not significantly different from those incontrol mice, whereas the magnitudes of gurmarin-insensitive components in db/db mice were about twice as large as those in control mice. These results suggest that the enhancement of chorda tympani responses in db/db mice to sucrose and other nonsugar sweeteners may occur through gurmarin-insensitive membrane components.

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Documento generato il 30/10/20 alle ore 00:24:18