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Titolo:
CARBACHOL STIMULATION OF GASTRIC-ACID SECRETION AND ITS EFFECTS ON THE PARIETAL-CELL
Autore:
SANDVIK AK; MARVIK R; DIMALINE R; WALDUM HL;
Indirizzi:
UNIV TRONDHEIM,MED TEK SENTER,DEPT PHYSIOL & BIOMED ENGN N-7005 TRONDHEIM NORWAY UNIV TRONDHEIM,DEPT MED N-7005 TRONDHEIM NORWAY UNIV TRONDHEIM,DEPT SURG N-7005 TRONDHEIM NORWAY UNIV LIVERPOOL,PHYSIOL LAB LIVERPOOL L69 3BX MERSEYSIDE ENGLAND
Titolo Testata:
British Journal of Pharmacology
fascicolo: 1, volume: 124, anno: 1998,
pagine: 69 - 74
SICI:
0007-1188(1998)124:1<69:CSOGSA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFUSED RAT STOMACH; SOMATOSTATIN-CONTAINING CELLS; ENTEROCHROMAFFIN-LIKE CELLS; MESSENGER-RNA ABUNDANCE; RABBIT FUNDIC MUCOSA; HISTAMINE-RELEASE; GENE-EXPRESSION; CCK RECEPTORS; PENTAGASTRIN; ACTIVATION;
Keywords:
ECL CELL; PARIETAL CELL; GASTRIN; HISTAMINE; MUSCARINIC; H+K+-ATPASE; HISTIDINE DECARBOXYLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Sandvik et al., "CARBACHOL STIMULATION OF GASTRIC-ACID SECRETION AND ITS EFFECTS ON THE PARIETAL-CELL", British Journal of Pharmacology, 124(1), 1998, pp. 69-74

Abstract

1 The acid secretagogue effect of gastrin is mainly mediated by the release of enterochromaffin-like (ECL) cell histamine, but the mechanism of muscarinic stimulation of acid secretion remains unclear. The results of studying aminopyrine uptake in isolated parietal cells, and histamine release in isolated ECL cells suggest that muscarinic agents may act both directly on the parietal cell and indirectly via histaminerelease from ECL cells. 2 We examined parietal and ECL cell responsesto the muscarinic agent carbamylcholine (carbachol) in conscious ratsand in rat isolated vascularly perfused stomachs. 3 Intravenous carbachol stimulated acid secretion in conscious gastric fistula rats and increased H+K+ ATPase mRNA abundance, indicating activation of parietalcells. In these experiments there was no increase in portal venous histamine, or in oxyntic mucosal histidine decarboxylase (HDC) enzyme activity and HDC mRNA abundance. 4 In rat isolated stomachs stimulated with carbachol in the dose range 10 nM-1 mM only the 1 mu M concentration increased venous histamine significantly. 5 We concluded that the muscarinic agent carbachol stimulates acid secretion and H+K+ ATPase mRNA in vivo by a direct effect on the parietal cell, that does not depend on the release of ECL cell histamine.

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Documento generato il 27/11/20 alle ore 22:17:19