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Titolo:
TREATMENT WITH ENALAPRIL MODIFIES THE PAIN PERCEPTION PATTERN IN HYPERTENSIVE PATIENTS
Autore:
GUASTI L; GRIMOLDI P; DIOLISI A; PETROZZINO MR; GAUDIO G; GRANDI AM; ROSSI MG; VENCO A;
Indirizzi:
UNIV HOSP,OSPED CIRCOLO,VIALE BORRI 57 I-21100 VARESE ITALY UNIV PAVIA,FAC MED 2,DEPT CLIN & BIOL SCI VARESE ITALY
Titolo Testata:
Hypertension
fascicolo: 5, volume: 31, anno: 1998,
pagine: 1146 - 1150
SICI:
0194-911X(1998)31:5<1146:TWEMTP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ARTERIAL BLOOD-PRESSURE; RENIN-ANGIOTENSIN SYSTEM; ELECTRICAL-STIMULATION; INDUCED ANALGESIA; BARORECEPTOR STIMULATION; ANGINA-PECTORIS; HUMANS; RATS; ANTINOCICEPTION; NOCICEPTION;
Keywords:
HYPERTENSION, ESSENTIAL; BLOOD PRESSURE MONITORING; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ENALAPRIL; PAIN THRESHOLD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
L. Guasti et al., "TREATMENT WITH ENALAPRIL MODIFIES THE PAIN PERCEPTION PATTERN IN HYPERTENSIVE PATIENTS", Hypertension, 31(5), 1998, pp. 1146-1150

Abstract

The cardiovascular system shares numerous anatomic and functional pathways with the antinociceptive network. The aim of this study was to investigate whether angiotensin-converting enzyme (ACE) inhibitor treatment could affect hypertension-related hypalgesia, Twenty-five untreated hypertensive patients, together with a control group of 14 normotensive subjects, underwent dental pain perception evaluation by means ofa pulpar test (graded increase of test current applied to healthy teeth). After the evaluation of the dental pain threshold (occurrence of pulp sensation) and tolerance (time when the subjects asked for the test to be stopped), all the subjects underwent a 24-hour ambulatory blood pressure monitoring. The hypertensive group then was treated with 20 mg/d enalapril, whereas the normotensive subjects remained without any treatment. After a time interval of 6+/-2 months, the dental pain sensitivity was retested in all the subjects, and ambulatory blood pressure was recorded during treatment in the hypertensive patients. At the first assessment, hypertensive patients showed a higher pain threshold than normotensive subjects (P<.001). On retesting of pain sensitivity in hypertensive patients, a significant decrease of both pain threshold and tolerance, leading to their normalization, was observed during treatment (P<.001 and P<.005, respectively), in the presence of reduced 24-hour and office blood pressure values. A slight, though significant, correlation was observed between variations in pain tolerance and baseline blood pressure changes occurring during treatment. During follow-up, the normotensive subjects did not show any significant pain perception or office blood pressure changes. Hypertension-related hypalgesia was confirmed. Mechanisms acting both through lowering of bloodpressure and specific pharmacodynamic properties may account for the normalization of pain sensitivity observed in hypertensive patients during treatment with ACE inhibitors.

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Documento generato il 29/09/20 alle ore 04:10:51