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Titolo:
REGIONAL EXPANSION DURING MYOCARDIAL-ISCHEMIA PREDICTS VENTRICULAR-FIBRILLATION AND CORONARY REOCCLUSION
Autore:
BARRABES JA; GARCIADORADO D; GONZALEZ MA; RUIZMEANA M; SOLARES J; PUIGFEL Y; SOLERSOLER J;
Indirizzi:
HOSP GEN VALLE HEBRON,SERV CARDIOL,PG VALL HEBRON 119-129 BARCELONA 08035 SPAIN HOSP GEN VALLE HEBRON,SERV CARDIOL BARCELONA 08035 SPAIN HOSP SAN PEDRO ALCANTARA,DEPT ANAT PATOL CACERES 10003 SPAIN
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 43, anno: 1998,
pagine: 1767 - 1775
SICI:
0363-6135(1998)43:5<1767:REDMPV>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ARRHYTHMIAS; ARTERY OCCLUSION; PORCINE HEART; INFARCT SIZE; REPERFUSION; THROMBOLYSIS; PROGNOSIS; TACHYCARDIA; NECROSIS; STENOSIS;
Keywords:
VENTRICULAR ARRHYTHMIAS; VENTRICULAR DILATATION; WALL MOTION CHANGES; STRETCH; MECHANOELECTRICAL FEEDBACK;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
J.A. Barrabes et al., "REGIONAL EXPANSION DURING MYOCARDIAL-ISCHEMIA PREDICTS VENTRICULAR-FIBRILLATION AND CORONARY REOCCLUSION", American journal of physiology. Heart and circulatory physiology, 43(5), 1998, pp. 1767-1775

Abstract

Primary ventricular fibrillation (VF) complicating acute myocardial infarction is associated with occluded infarction-related arteries. Therelationship between VF during ischemia and spontaneous coronary reocclusion was analyzed in 48 anesthetized pigs submitted to 48 min of coronary ligation and 6 h of reflow. Reocclusion was associated with ischemic VF (6 of 11 animals with VF but only 6 of 37 without it had reocclusion) but not with reperfusion arrhythmias, the size of the ischemic area, the magnitude of electrocardiogram changes or contractile dysfunction during ischemia, or the severity of intimal injury at the occlusion site. The increase in end-diastolic length in the ischemic region during coronary occlusion was associated with ischemic VF (15 min after occlusion, end-diastolic length was 116 +/- 2 and 111 +/- 1% of baseline in animals with or without presenting subsequent VF, respectively) and was retained by multiple logistic regression analysis as the only independent predictor of ischemic VF and reocclusion. Thus ischemic VF is strongly associated with an increased rate of spontaneous coronary reocclusion during subsequent reperfusion. Acute expansion of ischemic myocardium appears as a prominent determinant of both ischemic VF and reocclusion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 22:46:16