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Titolo:
IN-VIVO AND IN-VITRO MECHANICAL-PROPERTIES OF THE SHEEP THORACIC AORTA IN THE PERINATAL-PERIOD AND ADULTHOOD
Autore:
WELLS SM; LANGILLE BL; ADAMSON SL;
Indirizzi:
MT SINAI HOSP,SAMUEL LUNENFELD RES INST,600 UNIV AVE,RM 138-P TORONTOON M5G 1X5 CANADA MT SINAI HOSP,SAMUEL LUNENFELD RES INST TORONTO ON M5G 1X5 CANADA UNIV TORONTO,DEPT MET & MAT SCI TORONTO ON CANADA UNIV TORONTO,DEPT LAB MED & PATHOBIOL TORONTO ON CANADA UNIV TORONTO,DEPT OBSTET & GYNECOL TORONTO ON CANADA UNIV TORONTO,CTR BIOMAT TORONTO ON CANADA TORONTO HOSP,RES INST TORONTO ON M5T 2S8 CANADA
Titolo Testata:
American journal of physiology. Heart and circulatory physiology
fascicolo: 5, volume: 43, anno: 1998,
pagine: 1749 - 1760
SICI:
0363-6135(1998)43:5<1749:IAIMOT>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGE-RELATED-CHANGES; SCLEROPROTEIN CONTENT; CONNECTIVE-TISSUE; NUCLEIC-ACID; FETAL SHEEP; BLOOD-FLOW; RAT SKIN; COLLAGEN; ARTERIES; GROWTH;
Keywords:
ELASTICITY; WAVE PROPAGATION; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Wells et al., "IN-VIVO AND IN-VITRO MECHANICAL-PROPERTIES OF THE SHEEP THORACIC AORTA IN THE PERINATAL-PERIOD AND ADULTHOOD", American journal of physiology. Heart and circulatory physiology, 43(5), 1998, pp. 1749-1760

Abstract

The mammalian aorta undergoes rapid remodeling during the perinatal period and more gradual remodeling during subsequent development, but the implications of this remodeling for arterial mechanics are poorly understood. In this study in vivo and in vitro techniques were used to determine the static and viscoelastic properties of the thoracic aortas of 119-day-gestation fetal sheep (full term = 145 days), 21-day-old lambs, and adult sheep at control distending pressures and after 70% increases or 30% decreases in pressure. In the weeks surrounding birth,aortic wall tissue became substantially stiffer (static elastic modulus in vitro increased by 28%, and pressure wave velocity in vivo increased by 61%) but less viscous (pressure wave attenuation in vivo decreased by 46%, and viscoelastic phase angle in vitro decreased by 15%), whereas the wall thickness-to-radius ratio was unchanged. By contrast,modest changes in tissue viscoelasticity from neonatal to adult life were accompanied by a halving of the wall thickness-to-radius ratio from 0.19 +/- 0.01 to 0.10 +/- 0.01. The relative thinning of the vesselwall, combined with a doubling of blood pressure after birth, resulted in a 265% increase in aortic wall tensile stress over the period of study We concluded that rapid remodeling in the perinatal period primarily alters the viscoelastic properties of aortic wall tissues, whereas more gradual postnatal remodeling largely affects vessel geometry.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:43:01