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Titolo:
DIABETIC RATS ARE UNRESPONSIVE TO THE PENILE ERECTION-INDUCING EFFECTOF INTRACEREBROVENTRICULARLY INJECTED ADRENOCORTICOTROPIN
Autore:
POGGIOLI R; ARLETTI R; BENELLI A; CAVAZZUTI E; BERTOLINI A;
Indirizzi:
UNIV MODENA,DEPT BIOMED SCI,PHARMACOL SECT,VIA G CAMPI 287 I-41100 MODENA MO ITALY
Titolo Testata:
Neuropeptides
fascicolo: 2, volume: 32, anno: 1998,
pagine: 151 - 155
SICI:
0143-4179(1998)32:2<151:DRAUTT>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BEHAVIORAL SYNDROME; FEMALE SEXUAL-BEHAVIOR; OXYTOCIN; ACTH; ACETYLCHOLINE; APOMORPHINE; PEPTIDES; BRAIN; MSH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
R. Poggioli et al., "DIABETIC RATS ARE UNRESPONSIVE TO THE PENILE ERECTION-INDUCING EFFECTOF INTRACEREBROVENTRICULARLY INJECTED ADRENOCORTICOTROPIN", Neuropeptides, 32(2), 1998, pp. 151-155

Abstract

The penile erection-inducing effect of intracerebroventricularly (i.c.v.) injected adrenocorticotropin-(1-24) [ACTH-(1-24)] (4 or 10 mu g/animal) was almost completely absent in diabetic rats, either 8 days or2 months after streptozotocin administration. The other behavioral symptoms (stretching, yawning, excessive grooming) were unevenly affected: stretching was significantly reduced either in early or in long-standing diabetes; yawning was practically absent in early diabetes and significantly reduced at the highest dose of ACTH-(1-24) in long-standing diabetes; grooming was reduced only at the highest dose of ACTH-(1-24), both in early and in long-standing diabetes. The fact that ACTH-induced penile erections (a centrally mediated effect) are practically absent even a few days after streptozotocin injection suggests that diabetes mellitus-induced penile dysfunction occurs, at least in part, through central mechanisms, and is not solely the consequence of peripheral nerve and vascular lesions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:29:19