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Titolo:
HIPPOCAMPAL VOLUME REDUCTION IN SCHIZOPHRENIA AS ASSESSED BY MAGNETIC-RESONANCE-IMAGING - A METAANALYTIC STUDY
Autore:
NELSON MD; SAYKIN AJ; FLASHMAN LA; RIORDAN HJ;
Indirizzi:
DARTMOUTH COLL SCH MED,DARTMOUTH HITCHCOCK MED CTR,DEPT PSYCHIAT,BRAIN IMAGING LAB,1 MED CTR DR LEBANON NH 03756 DARTMOUTH COLL SCH MED,DARTMOUTH HITCHCOCK MED CTR,DEPT PSYCHIAT,BRAIN IMAGING LAB LEBANON NH 03756 DARTMOUTH COLL SCH MED,DARTMOUTH HITCHCOCK MED CTR,DEPT RADIOL LEBANON NH 03756 NEW HAMPSHIRE HOSP CONCORD NH 00000 DARTMOUTH COLL,DEPT PSYCHOL HANOVER NH 03755
Titolo Testata:
Archives of general psychiatry
fascicolo: 5, volume: 55, anno: 1998,
pagine: 433 - 440
SICI:
0003-990X(1998)55:5<433:HVRISA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
MONOZYGOTIC TWINS DISCORDANT; FIRST-EPISODE SCHIZOPHRENIA; FRONTAL-LOBE DYSFUNCTION; SUPERIOR TEMPORAL GYRUS; BRAIN MORPHOLOGY; PARAHIPPOCAMPAL GYRUS; P300 ABNORMALITIES; AFFECTIVE-DISORDER; MEMORY; SIZE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
84
Recensione:
Indirizzi per estratti:
Citazione:
M.D. Nelson et al., "HIPPOCAMPAL VOLUME REDUCTION IN SCHIZOPHRENIA AS ASSESSED BY MAGNETIC-RESONANCE-IMAGING - A METAANALYTIC STUDY", Archives of general psychiatry, 55(5), 1998, pp. 433-440

Abstract

Background: Although many quantitative magnetic resonance imaging studies have found significant volume reductions in the hippocampi of patients with schizophrenia compared with those of normal control subjects, others have not. Therefore, the issue of hippocampal volume differences associated with schizophrenia remains in question. Methods: Two meta-analyses were conducted to reduce the potential effects of sampling error and methodological differences in data acquisition and analysis. Eighteen studies with a total patient number of 522 and a to tal control number of 426 met the initial selection criteria. Results: Meta-analysis 1 yielded mean effect sizes of 0.37 (P<.001) for the left hippocampus and 0.39 (P<.001) for the right, corresponding to a bilateralreduction of 4%. Meta-analysis 2 indicated that the inclusion of the amygdala in the region of interest significantly increased effect sizes across studies (effect size for the left hippocampus and amygdala, 0.67; for the right, 0.72), whereas variables such as illness duration,total slice width, magnet strength, the use of the intracranial volume as a covariate, measurement reliability, and study quality did not. No laterality differences were observed in these data. Conclusions: Schizophrenia is associated with a bilateral volumetric reduction of thehippocampus and probably of the amygdala as well. These findings reinforce the importance of the medial temporal region in schizophrenia and are consistent with frequently reported memory deficits in these patients. Future quantitative magnetic resonance imaging studies evaluating the hippocampal volume should measure the hippocampus and amygdala separately and compare the volumetric reduction in these structures tothat observed in other gray matter areas.

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Documento generato il 22/01/20 alle ore 12:47:40