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Titolo:
EXPRESSION OF DIFFERENT HIV-1 PHENOTYPIC SUBPOPULATIONS THROUGH THE NATURAL-HISTORY OF THE INFECTION
Autore:
ALVAREZ LP; VERDEJO J; LAHOZ JG; GURBINDO D; HERNANDEZSAMPELAYO T; MORENO E; AZANEDO M; CONTRERAS G; MEDRANO L; NAJERA R;
Indirizzi:
INST SALUD CARLOS III,CTR NACL BIOL FUNDAMENTAL,UNIDAD INVEST RETROVIRUS MADRID 28220 SPAIN INST SALUD CARLOS III,CTR NACL BIOL FUNDAMENTAL,UNIDAD INVEST RETROVIRUS MADRID 28220 SPAIN INST SALUD CARLOS III,CTR INVEST CLIN & MED PREVENT,SERV ENFERMEDADESINFECCIOSAS MADRID 28220 SPAIN HOSP INFANTIL GREGORIO MARANON,SECCIONES IMMUNOPED MADRID SPAIN HOSP INFANTIL GREGORIO MARANON,SECCIONES ENFERMEDADES INFECCIOSAS PEDIAT MADRID SPAIN
Titolo Testata:
Medicina Clinica
fascicolo: 12, volume: 110, anno: 1998,
pagine: 441 - 445
SICI:
0025-7753(1998)110:12<441:EODHPS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
SPA
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; BIOLOGICAL PHENOTYPE; VIRAL PHENOTYPE; PROGRESSION; VARIANTS; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
L.P. Alvarez et al., "EXPRESSION OF DIFFERENT HIV-1 PHENOTYPIC SUBPOPULATIONS THROUGH THE NATURAL-HISTORY OF THE INFECTION", Medicina Clinica, 110(12), 1998, pp. 441-445

Abstract

BACKGROUND: Multiple viral subpopulations coexist in an HIV infected patient with dynamics of selection established between them. In order to get insight on the phenotype of these subpoblations, and its relation with disease progression, we have studied the biological variability of HIV-1 in 113 patients. Variability was related with CD4+ T lymphocyte counts, clinical status, way of viral transmission and antiretroviral treatment. PATIENTS AND METHODS: 113 patients (80 adults and 33 children) were studied for HIV-I isolation in cocultures of infected and non infected lymphocytes, Viral replication was evaluated as rapid (R)/slow (S) or high (H)/low (L). Syncytia formation was estimated in MT2 cell line (SI/NSI). The tropism toward lymphocytes and monocytes (LM) was studied on H9 and U937 cell lines, RESULTS: UP to 86.7% of viral isolates were R, 56.6% were H and 49.6% were SI. These percentages increased with disease progression. Eight viral strains were R/H/NSI cocultivated in MT2 cells and SI in cocultured lymphocytes (NSI/SI), which may be considered as a new phenotype. All the SI isolates and all the WH (SI and NSI) isolates were LM. Three categories were estabilished: R/H/SI/LM, R/H/NSI/LM and S/L/NSI/NLM. The first two categories corresponded to patients with CD4+ T lymphocytes < 200 x 10(6)/I (56%, 50%), The third category corresponded to patients with > 500 x 10(6)/1 (53.3%), CONCLUSIONS: Viral replication and SI phenotype, independently, are useful markers for severity of HIV infection. The biological differencies among NSI of the 3 viral phenotype categories, including thenew subgroup NSI/SI, may indicate the existence of more pathogenic NSI subpopulations.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:08:14