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Titolo:
DONEPEZIL
Autore:
WHITEHOUSE PJ;
Indirizzi:
CASE WESTERN RESERVE UNIV,UNIV ALZHEIMER CTR,12200 FAIRHILL RD,SUITE B320 CLEVELAND OH 44120 CASE WESTERN RESERVE UNIV,UNIV HOSP CLEVELAND CLEVELAND OH 00000
Titolo Testata:
Medicamentos de actualidad
fascicolo: 4, volume: 34, anno: 1998,
pagine: 321 - 326
SICI:
0025-7656(1998)34:4<321:>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALZHEIMERS-DISEASE; CHOLINESTERASE-INHIBITORS; SENILE DEMENTIA; E2020; ACETYLCHOLINESTERASE; EFFICACY; RATS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Whitehouse, "DONEPEZIL", Medicamentos de actualidad, 34(4), 1998, pp. 321-326

Abstract

Donepezil is a highly selective, long-acting acetylcholinesterase inhibitor which has been approved in numerous countries for the treatmentof Alzheimer's disease. Donepezil increases the levels of acetylcholine in the brain of patients with Alzheimer's disease and presumably corrects some dysfunction associated with loss of cells in the basal forebrain. Several large-scale multinational clinical studies have demonstrated drug-related improvements in cognitive performance on objectivepsychometric tests and in ratings by clinicians of patients' function. Further studies will be needed to determine the long-term impact of donepezil on Alzheimer's disease and related dementias. (C) 1998 ProusScience. All rights reserved.

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Documento generato il 30/09/20 alle ore 09:19:54