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Titolo:
INTRACRANIAL VOLUME IN CRANIOSYNOSTOTIC RABBITS
Autore:
MOONEY MP; BURROWS AM; WIGGINTON W; SINGHAL VK; LOSKEN HW; SMITH TD; DECHANT J; TOWBIN A; COOPER GM; TOWBIN R; SIEGEL MI;
Indirizzi:
UNIV PITTSBURGH,DEPT ANAT & HISTOL,619 SALK HALL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ANTHROPOL PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT PLAST & RECONSTRUCT SURG PITTSBURGH PA 15261 UNIV PITTSBURGH,DEPT ORTHODONT PITTSBURGH PA 15261 UNIV PITTSBURGH,CLEFT PALATE CRANIOFACIAL CTR PITTSBURGH PA 15261 UNIV PITTSBURGH,DIV PLAST SURG PITTSBURGH PA 15261 UNIV PITTSBURGH,SCH NURSING PITTSBURGH PA 15261 SLIPPERY ROCK UNIV,SCH PHYS THERAPY SLIPPERY ROCK PA 16057 UNIV PITTSBURGH,MED CTR,DEPT RADIOL PITTSBURGH PA 00000 CHILDRENS HOSP,DEPT PEDIAT PLAST SURG PITTSBURGH PA 15213 UNIV MISSOURI,SECT PLAST SURG KANSAS CITY MO 64110 CHILDRENS MERCY HOSP,CLEFT PALATE CRANIOFACIAL PROGRAM KANSAS CITY MO64108 CHILDRENS HOSP,DEPT RADIOL PITTSBURGH PA 15213 UNIV PITTSBURGH,SCH MED,DEPT PEDIAT PITTSBURGH PA 15261
Titolo Testata:
The Journal of craniofacial surgery
fascicolo: 3, volume: 9, anno: 1998,
pagine: 234 - 239
SICI:
1049-2275(1998)9:3<234:IVICR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONAL SUTURE SYNOSTOSIS; APERT SYNDROME; CRANIAL VAULT; CT-SCANS; PRESSURE; CHILDREN; GROWTH; CHILDHOOD; CROUZON; PATTERN;
Keywords:
CRANIOSYNOSTOSIS; RABBITS; INTRACRANIAL VOLUME; BRAIN; COMPUTED TOMOGRAPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Mooney et al., "INTRACRANIAL VOLUME IN CRANIOSYNOSTOTIC RABBITS", The Journal of craniofacial surgery, 9(3), 1998, pp. 234-239

Abstract

Although craniosynostosis alters brain growth direction resulting in compensatory changes in the neurocranium, it has been suggested that such compensations occur with little reduction in intracranial volume (ICV). This hypothesis was tested in a rabbit model with nonsyndromic, familial coronal suture synostosis. Cross-sectional three-dimensional computed tomographic head scans were obtained from 79 rabbits (25 normal, 28 with delayed-onset synostosis, and 26 with early-onset synostosis) at 25, 42, and 126 days of age. Intracranial contents were reconstructed and indirect ICV was calculated. Results revealed that by 25 days of age the intracranial contents from early-onset synostosed rabbitskulls showed rostral (anterior) constrictions and a ''beaten copper'' morphology in the parietal and temporal regions compared with the other two groups. These deformities increased in severity with age. Quantitatively, ICV was significantly reduced (p < 0.05) by 7% in rabbits with early-onset synostosis compared with both control rabbits and rabbits with delayed-onset synostosis at 25 days of age. By 126 days of age, ICV in rabbits with synostosis was significantly reduced (p < 0.05) by 11% in early-onset synostosis and by 8% in delayed-onset synostosis compared with normal rabbits. Results suggest that in rabbits with uncorrected craniosynostosis, compensatory changes in the neurocraniumwere not adequate to allow normal expansion of the neurocapsular matrix. Further research is needed to determine if ICV reduction is correlated with cerebral atrophy or cerebral spinal fluid (i.e., ventricularor subarachnoid) space compression in this model.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 10:13:00