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Titolo:
EVOLUTION OF SYNCYTIUM-INDUCING AND NON-SYNCYTIUM-INDUCING BIOLOGICALVIRUS CLONES IN RELATION TO REPLICATION KINETICS DURING THE COURSE OFHUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION
Autore:
VANTWOUT AB; BLAAK H; RAN LJ; BROUWER M; KUIKEN C; SCHUITEMAKER H;
Indirizzi:
NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL,PLESMANLAAN 125 NL-1066 CX AMSTERDAM NETHERLANDS NETHERLANDS RED CROSS,BLOOD TRANSFUS SERV,CENT LAB,DEPT CLIN VIROIMMUNOL NL-1066 CX AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,EXPT & CLIN IMMUNOL LAB NL-1105 AZ AMSTERDAM NETHERLANDS LOS ALAMOS NATL LAB,HIV DATABASE & ANAL GRP LOS ALAMOS NM 00000
Titolo Testata:
Journal of virology
fascicolo: 6, volume: 72, anno: 1998,
pagine: 5099 - 5107
SICI:
0022-538X(1998)72:6<5099:EOSANB>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELL-LINE; PRIMARY HIV-1 ISOLATE; REVERSE-TRANSCRIPTASE; VIRAL PHENOTYPE; GENE; DOMAIN; PROGRESSION; MACROPHAGE; RECEPTOR; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
A.B. Vantwout et al., "EVOLUTION OF SYNCYTIUM-INDUCING AND NON-SYNCYTIUM-INDUCING BIOLOGICALVIRUS CLONES IN RELATION TO REPLICATION KINETICS DURING THE COURSE OFHUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION", Journal of virology, 72(6), 1998, pp. 5099-5107

Abstract

To investigate the temporal relationship between human immunodeficiency virus type 1 (HIV-1) replicative capacity and syncytium-inducing (SI) phenotype, biological and genetic characteristics of longitudinallyobtained virus clones from two HIV-1-infected individuals who developed SI variants were studied. In one individual, the emergence of rapidly replicating SI and non-syncytium-inducing (NSI) variants was accompanied by a loss of the slowly replicating NSI variants. In the other subject, NSI variants were always slowly replicating, while the coexisting SI variants showed an increase in the rate of replication. Irrespective their replicative capacity, the NSI variants remained present throughout the infection in both individuals. Phylogenetic analysis of the V3 region showed early branching of the SI variants from the NSI tree. Successful SI conversion seemed a unique event since no SI variants were found among later-stage NSI variants. This was also confirmed by the increasing evolutionary distance between the two subpopulations. At any time point during the course of the infection, the variation within the coexisting SI and NSI populations did not exceed 2%, indicating continuous competition within each viral subpopulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:17:36