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Titolo:
VACCINATION WITH DNA ENCODING AN IMMUNODOMINANT MYELIN BASIC-PROTEIN PEPTIDE TARGETED TO FC OF IMMUNOGLOBULIN-G SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
Autore:
LOBELL A; WEISSERT R; STORCH MK; SVANHOLM C; DEGRAAF KL; LASSMANN H; ANDERSSON R; OLSSON T; WIGZELL H;
Indirizzi:
PHARMACIA & UPJOHN INC,P124 S-11287 STOCKHOLM SWEDEN KAROLINSKA INST,MICROBIOL & TUMORBIOL CTR S-17177 STOCKHOLM SWEDEN KAROLINSKA HOSP,CTR MOL MED,NEUROIMMUNOL UNIT S-17176 STOCKHOLM SWEDEN UNIV VIENNA,INST NEUROL A-1090 VIENNA AUSTRIA
Titolo Testata:
The Journal of experimental medicine
fascicolo: 9, volume: 187, anno: 1998,
pagine: 1543 - 1548
SICI:
0022-1007(1998)187:9<1543:VWDEAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERFERON-GAMMA; IMMUNIZATION; CELLS; GENE; INFLUENZA; RESPONSES; TOLERANCE; CYTOKINES; IMMUNITY; RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
A. Lobell et al., "VACCINATION WITH DNA ENCODING AN IMMUNODOMINANT MYELIN BASIC-PROTEIN PEPTIDE TARGETED TO FC OF IMMUNOGLOBULIN-G SUPPRESSES EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS", The Journal of experimental medicine, 187(9), 1998, pp. 1543-1548

Abstract

We explore here if vaccination with DNA encoding an autoantigenic peptide can suppress autoimmune disease. For this purpose we used experimental autoimmune encephalomyelitis (EAE), which is an autoaggressive disease in the central nervous system and an animal model for multiple sclerosis. Lewis rats were vaccinated with DNA encoding an encephalitogenic T cell epitope, guinea pig myelin basic protein peptide 68-85 (MBP68-85), before induction of EAE with MBP68-85 in complete Freund's adjuvant. Compared to vaccination with a control DNA construct, the vaccination suppressed clinical and histopathological signs of EAE, and reduced the interferon gamma production after challenge with MBP68-85. Targeting of the gene product to Fc of IgG was essential for this effect. There were no signs of a Th2 cytokine bias. Our data suggest that DNA vaccines encoding autoantigenic peptides may be useful tools in controlling autoimmune disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:16:41