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Titolo:
EFFECTS OF DAMAGE TO THE BASAL FOREBRAIN ON BRAIN GLUCOSE-UTILIZATION- A REEVALUATION USING POSITRON-EMISSION-TOMOGRAPHY IN BABOONS WITH EXTENSIVE UNILATERAL EXCITOTOXIC LESION
Autore:
LEMESTRIC C; CHAVOIX C; CHAPON F; MEZENGE F; EPELBAUM J; BARON JC;
Indirizzi:
CEA,INSERM,U320,CYCERON,DSV,DPTE,BP 5229 F-14074 CAEN FRANCE CEA,INSERM,U320,CYCERON,DSV,DPTE F-14074 CAEN FRANCE CHU CAEN,SERV NEUROL DEJERINE F-14000 CAEN FRANCE INSERM,U159 PARIS FRANCE
Titolo Testata:
Journal of cerebral blood flow and metabolism
fascicolo: 5, volume: 18, anno: 1998,
pagine: 476 - 490
SICI:
0271-678X(1998)18:5<476:EODTTB>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLINE-ACETYLTRANSFERASE ACTIVITY; IBOTENIC-ACID LESIONS; ALZHEIMERS-DISEASE; NUCLEUS BASALIS; SUBSTANTIA INNOMINATA; CEREBRAL-CORTEX; GLOBUS PALLIDUS; SENILE DEMENTIA; NEURONS; METABOLISM;
Keywords:
ACETYLCHOLINE; NUCLEUS OF MEYNERT; ALZHEIMERS DISEASE; F-18 FLUORO-2-DEOXY-D-GLUCOSE; NONHUMAN PRIMATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
56
Recensione:
Indirizzi per estratti:
Citazione:
C. Lemestric et al., "EFFECTS OF DAMAGE TO THE BASAL FOREBRAIN ON BRAIN GLUCOSE-UTILIZATION- A REEVALUATION USING POSITRON-EMISSION-TOMOGRAPHY IN BABOONS WITH EXTENSIVE UNILATERAL EXCITOTOXIC LESION", Journal of cerebral blood flow and metabolism, 18(5), 1998, pp. 476-490

Abstract

Neuronal loss in the basal forebrain cholinergic structures and frontotemporal hypometabolism an two characteristics of Alzheimer's disease, but their interrelations still an unsettled. We previously reported that unilateral electrolytic lesions of the nucleus basalis of Meynertin baboons were associated with marked but transient cortical hypometabolism. The current study reevaluates this issue using improved methodology. Baboons with unilateral ibotenic acid lesion of all three basal forebrain cholinergic structures (IBO group) were compared with sham-operated animals. The CMRglc was measured with high-resolution coronal positron emission tomography scanning coregistered with magnetic resonance imaging, before surgery and serially between 4 and 72 days afterward. Severe histologic basal forebrain damage and a decrease of morethan 50% in cortical choline acetyltransferase activity were found postmortem in the IBO group. Transient and non-specific hypometabolism was found in the needle track area in both groups. Compared with the sham-operated group, only marginally significant decreases in ipsilateral-contralateral CMRglc ratios were observed in the IBO group, affecting only 1 of 14 neocortical areas investigated (the anterior temporal cortex) at a single postsurgical time (day 14), and the posterior hippocampal region at days 14 and 38, Furthermore, there was no consistently significant correlation between ipsilateral-contralateral CMRglc ratios and cortical choline acetyltransferase activity values in any of the four regions analyzed. These results suggest that cholinergic deafferentation play at best a marginal role in the brain hypometabolism observed in Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:32:43