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Titolo:
BIOCHEMICAL BONE MARKERS, BONE-MINERAL CONTENT, AND BONE-MINERAL DENSITY IN RATS WITH EXPERIMENTAL NEPHROTIC SYNDROME
Autore:
SIERRA RI; SPECKER BL; JIMENEZ F; CRUZ C; PEDRAZACHAVERRI J;
Indirizzi:
CHILDRENS HOSP,DEPT PEDIAT,PEDIAT BONE RES CTR,231 BETHESDA AVE CINCINNATI OH 45267
Titolo Testata:
Renal failure
fascicolo: 3, volume: 19, anno: 1997,
pagine: 409 - 424
SICI:
0886-022X(1997)19:3<409:BBMBCA>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
VITAMIN-D METABOLISM; CONVERTING ENZYME-ACTIVITY; NORMAL RENAL-FUNCTION; PUROMYCIN AMINONUCLEOSIDE; URINARY-EXCRETION; GLA-PROTEIN; CALCIUM-METABOLISM; SERUM OSTEOCALCIN; SODIUM RETENTION; PLASMA-LEVELS;
Keywords:
DUAL-ENERGY X-RAY ABSORPTIOMETRY; NEPHROTIC SYNDROME; OSTEOCALCIN; PUROMYCIN AMINONUCLEOSIDE; PYRIDINOLINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
79
Recensione:
Indirizzi per estratti:
Citazione:
R.I. Sierra et al., "BIOCHEMICAL BONE MARKERS, BONE-MINERAL CONTENT, AND BONE-MINERAL DENSITY IN RATS WITH EXPERIMENTAL NEPHROTIC SYNDROME", Renal failure, 19(3), 1997, pp. 409-424

Abstract

The human nephrotic syndrome (NS) is accompanied by important alterations of mineral and bone metabolism. The purpose of the present study was to examine bone metabolism in rats with experimental NS and normalcreatinine clearance, and to evaluate the reversibility of this alteration. NS was induced by three injections of puromycin aminonucleoside(PAN) on days 0, 21, and 35 (10, 5, and 5 mg/100 g body weight, respectively). The biochemical markers of bone formation (osteocalcin and alkaline phosphatase) and bone resorption (hydroxyproline and pyridinoline), bone mineral content (BMC), and bone mineral density (BMD), determined by dual-energy x-ray absorptiometry (DEXA), were studied on days 0, 7, 24, 28, 42, 56, 84, and 112. Proteinuria was present throughout the study. Hypoproteinemia was seen on days 7, 28, 42, and 56, returning to control values on days 84 and 112. In serum, osteocalcin (OC) concentration increased (p < 0.001), and alkaline phosphatase (ALP) decreased (p = 0.002). In urine, hydroxyproline increased (p < 0.001), but urinary pyridinoline was not different from the control group throughout the study. Increased serum parathyroid hormone concentration anddecreased levels of 25-hydroxy and 1,25-dihydroxyvitamin D were foundfrom day 7. During the intense proteinura, bone resorption predominates and decreased BMC and BMD ensues in PAN-nephrotic rats. PAN-nephrotic rats showed low BMC and BMD compared to control group (p < 0.001). At the end of the study, when proteinuria persisted but total serum protein returned to control values, the biochemical bone markers, BMC, and BMD returned to normal. In conclusion, PAN-nephrotic rats had reversible bone alterations that were related to the magnitude of proteinuria and the concentration of total serum protein.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:42:40