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Titolo:
MEMORY MODULATION ACROSS NEURAL SYSTEMS - INTRAAMYGDALA GLUCOSE REVERSES DEFICITS CAUSED BY INTRASEPTAL MORPHINE ON A SPATIAL TASK BUT NOT ON AN AVERSIVE TASK
Autore:
MCNAY EC; GOLD PE;
Indirizzi:
UNIV VIRGINIA,DEPT PSYCHOL,102 GILMER HALL CHARLOTTESVILLE VA 22903 UNIV VIRGINIA,NEUROSCI PROGRAM CHARLOTTESVILLE VA 22903
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 18, anno: 1998,
pagine: 3853 - 3858
SICI:
0270-6474(1998)18:10<3853:MMANS->2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAUDATE-NUCLEUS LESIONS; WORKING-MEMORY; SPONTANEOUS-ALTERNATION; TRIPLE DISSOCIATION; MAZE TASKS; HIPPOCAMPUS; ATTENUATION; INTERFERENCE; IMPAIRMENTS; ACQUISITION;
Keywords:
GLUCOSE; MEMORY; NEURAL SYSTEMS; MEDIAL SEPTUM; AMYGDALA; MORPHINE; SPONTANEOUS ALTERNATION; INHIBITORY AVOIDANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
E.C. Mcnay e P.E. Gold, "MEMORY MODULATION ACROSS NEURAL SYSTEMS - INTRAAMYGDALA GLUCOSE REVERSES DEFICITS CAUSED BY INTRASEPTAL MORPHINE ON A SPATIAL TASK BUT NOT ON AN AVERSIVE TASK", The Journal of neuroscience, 18(10), 1998, pp. 3853-3858

Abstract

Based largely on dissociations of the effects of different lesions onlearning and memory, memories for different attributes appear to be organized in independent neural systems, Results obtained with direct injections of drugs into one brain region at a time support a similar conclusion, The present experiments investigated the effects of simultaneous pharmacological manipulation of two neural systems, the amygdalaand the septohippocampal system, to examine possible interactions of memory modulation across systems. Morphine injected into the medial septum impaired memory both for avoidance training and during spontaneous alternation. When glucose was concomitantly administered to the amygdala, glucose reversed the morphine-induced deficits in memory during alternation but not for avoidance training, These results suggest thatthe amygdala is involved in modulation of spatial memory processes and that direct injections of memory-modulating drugs into the amygdala do not always modulate memory for aversive events. These findings are contrary to predictions from the findings of lesion studies and of studies using direct injections of drugs into single brain areas. Thus, the independence of neural systems responsible for processing differentclasses of memory is less clear than implied by studies using lesionsor injections of drugs into single brain areas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 16:48:30