Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DEFECTIVE MOTOR BEHAVIOR AND NEURAL GENE-EXPRESSION IN RII-BETA PROTEIN-KINASE-A MUTANT MICE
Autore:
BRANDON EP; LOGUE SF; ADAMS MR; QI M; SULLIVAN SP; MATSUMOTO AM; DORSA DM; WEHNER JM; MCKNIGHT GS; IDZERDA RL;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACOL,BOX 356650 SEATTLE WA 98195 VET AFFAIRS PUGET SOUND HLTH CARE SYST,DEPT PHARMACOL SEATTLE WA 00000 VET AFFAIRS PUGET SOUND HLTH CARE SYST,DEPT MED SEATTLE WA 00000 VET AFFAIRS PUGET SOUND HLTH CARE SYST,CTR GERIATR RES EDUC & CLIN SEATTLE WA 00000 UNIV WASHINGTON,SCH MED,DEPT PSYCHIAT & BEHAV SCI SEATTLE WA 98195 UNIV COLORADO,INST BEHAV GENET BOULDER CO 80309
Titolo Testata:
The Journal of neuroscience
fascicolo: 10, volume: 18, anno: 1998,
pagine: 3639 - 3649
SICI:
0270-6474(1998)18:10<3639:DMBANG>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; REGULATORY SUBUNIT; MESSENGER-RNA; NUCLEUS-ACCUMBENS; BASAL GANGLIA; C-FOS; TARGETED DISRUPTION; DOPAMINE-RECEPTORS; PRODYNORPHIN GENE; AGED RATS;
Keywords:
CAMP-DEPENDENT PROTEIN KINASE; PKA; KNOCKOUT; MOUSE; STRIATUM; DOPAMINE; AMPHETAMINE; LOCOMOTION; ROTAROD; SENSITIZATION; FOS; DYNORPHIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
74
Recensione:
Indirizzi per estratti:
Citazione:
E.P. Brandon et al., "DEFECTIVE MOTOR BEHAVIOR AND NEURAL GENE-EXPRESSION IN RII-BETA PROTEIN-KINASE-A MUTANT MICE", The Journal of neuroscience, 18(10), 1998, pp. 3639-3649

Abstract

Motor behavior is modulated by dopamine-responsive neurons in the striatum, where dopaminergic signaling uses G-protein-coupled pathways, including those that result in the activation of cAMP-dependent proteinkinase (PKA). The RII beta isoform of PKA is highly enriched in the striatum, and targeted disruption of the RII beta gene in mice leads toa dramatic reduction in total PKA activity in this region. Although the mutant mice show typical locomotor responses after acute administration of dopaminergic drugs, they display abnormalities in two experience-dependent locomotor behaviors: training on the rotarod task and locomotor sensitization to amphetamine. In addition, amphetamine induction of fos is absent, and the basal expression of dynorphin mRNA is reduced in the striatum. These results demonstrate that motor learning andthe regulation of neuronal gene expression require RII beta PKA, whereas the acute locomotor effects of dopaminergic drugs are relatively unaffected by this PKA deficiency.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:14:23