Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CALORIC-INTAKE ALTERS THE EFFICIENCY OF CATALASE MESSENGER-RNA TRANSLATION IN THE LIVER OF OLD FEMALE MICE
Autore:
DHAHBI JM; TILLMAN JB; CAO S; MOTE PL; WALFORD RL; SPINDLER SR;
Indirizzi:
UNIV CALIF RIVERSIDE,DEPT BIOCHEM RIVERSIDE CA 92521 UNIV CALIF RIVERSIDE,DEPT BIOCHEM RIVERSIDE CA 92521 UNIV CALIF LOS ANGELES,SCH MED,DEPT PATHOL LOS ANGELES CA 90024
Titolo Testata:
The journals of gerontology. Series A, Biological sciences and medical sciences
fascicolo: 3, volume: 53, anno: 1998,
pagine: 180 - 185
SICI:
1079-5006(1998)53:3<180:CATEOC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; DIETARY RESTRICTION; LIPID-PEROXIDATION; OXIDATIVE DAMAGE; DROSOPHILA-MELANOGASTER; ANTIOXIDANT ENZYMES; FOOD RESTRICTION; TISSUE SAMPLES; MOUSE-LIVER; AGING RATS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Dhahbi et al., "CALORIC-INTAKE ALTERS THE EFFICIENCY OF CATALASE MESSENGER-RNA TRANSLATION IN THE LIVER OF OLD FEMALE MICE", The journals of gerontology. Series A, Biological sciences and medical sciences, 53(3), 1998, pp. 180-185

Abstract

The free radical theory of aging pr edicts that calorie restriction, which extends life span, should reduce oxidant damage. In mammals, theoxidative processes centered in the liver are a major source of free radicals. Liver catalase has the dominant role in the intracellular detoxification of hydrogen peroxide. In male rodents, published studies indicate that aging decreases catalase gene transcription and that calorie restriction obviates this effect. In females, published studies are inconsistent, and no molecular mechanisms have been identified. Here we report that, in female mice, aging can lead to an increase in thetranslational efficiency of hepatic catalase mRNA, and that calorie restriction obviates this effect. Consideration of these results and published studies leads us to propose that the variability in catalase results in females may arise from the small number of studies or from unique aspects of female physiology, perhaps the estrous cycle and its cessation with age.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 11:18:58