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Titolo:
EFFICACY OF ANALGESICS IN CHRONIC PAIN - A SERIES OF N-OF-L STUDIES
Autore:
SHEATHERREID RB; COHEN ML;
Indirizzi:
ST VINCENTS MED CTR,376-382 VICTORIA ST DARLINGHURST NSW 2010 AUSTRALIA ST VINCENTS HOSP,DEPT RHEUMATOL SYDNEY NSW 2010 AUSTRALIA
Titolo Testata:
Journal of pain and symptom management
fascicolo: 4, volume: 15, anno: 1998,
pagine: 244 - 252
SICI:
0885-3924(1998)15:4<244:EOAICP>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL PATIENTS; RANDOMIZED TRIALS; FIBROMYALGIA; GUIDE;
Keywords:
CHRONIC MUSCULOSKELETAL PAIN; N-OF-1 STUDIES; ANALGESIC TREATMENT; IBUPROFEN; CODEINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
R.B. Sheatherreid e M.L. Cohen, "EFFICACY OF ANALGESICS IN CHRONIC PAIN - A SERIES OF N-OF-L STUDIES", Journal of pain and symptom management, 15(4), 1998, pp. 244-252

Abstract

Rational drug treatment of chronic musculoskeletal pain remains a challenge. Although commonly prescribed the true efficacy of opioid analgesics or of nonsteroidal antiinflammatory drugs remains to be established. Using an N-of-1 design, eight patients with regional cervicobrachial pain received ibuprofen 800 mg/day, codeine 120 mg/day, or placebocluing six 2-week periods. Clinical outcomes were assessed by pain diary, VAS of pain and change in pain, and uptime/downtime estimates. Innone of the five subjects who completed the 12-week trial was analgesic efficacy of either drug shown. Major psychosocial and other medicalinfluences on the subjects' status were encountered. The N-of-1 methodology is appropriate for evaluating true efficacy of pharmacotherapy in patients with regional musculoskeletal pain. (C) U.S. Cancer Pain Relief Committee, 1998.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:03:10