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Titolo:
CHANGES IN THE HEPATIC MITOCHONDRIAL RESPIRATORY SYSTEM IN THE TRANSITION FROM WEANING TO ADULTHOOD IN RATS
Autore:
LIONETTI L; IOSSA S; LIVERINI G; BRAND MD;
Indirizzi:
UNIV NAPLES,DIPARTIMENTO FISIOL GEN & AMBIENTALE,VIA MEZZOCANNONE 8 I-80134 NAPLES ITALY UNIV NAPLES,DIPARTIMENTO FISIOL GEN & AMBIENTALE I-80134 NAPLES ITALY UNIV CAMBRIDGE,DEPT BIOCHEM CAMBRIDGE CB2 1QW ENGLAND
Titolo Testata:
Archives of biochemistry and biophysics
fascicolo: 2, volume: 352, anno: 1998,
pagine: 240 - 246
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVER-MITOCHONDRIA; DEVELOPMENTAL-CHANGES; INNER MEMBRANE; OXIDATIVE-PHOSPHORYLATION; POSTNATAL-DEVELOPMENT; ADENINE-NUCLEOTIDES; STATE-3 RESPIRATION; PERINATAL-PERIOD; GENE-EXPRESSION; PERMEABILITY;
Keywords:
MITOCHONDRIA; OXYGEN CONSUMPTION; TOP-DOWN ELASTICITY ANALYSIS; WEANING-ADULTHOOD TRANSITION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
L. Lionetti et al., "CHANGES IN THE HEPATIC MITOCHONDRIAL RESPIRATORY SYSTEM IN THE TRANSITION FROM WEANING TO ADULTHOOD IN RATS", Archives of biochemistry and biophysics, 352(2), 1998, pp. 240-246

Abstract

In the present study we investigated the changes in the hepatic mitochondrial respiratory system in the transition from weaning to adulthood in the rat. We conceptually divided the system into blocks of reactions that produced or consumed mitochondrial membrane potential and then measured the kinetic responses of these blocks of reactions to changes in this potential in isolated liver mitochondria from 25- and 60-day-old rats using succinate as substrate. Moreover, we considered the mitochondrial membrane potential producers to be divided into blocks ofreactions that reduced or oxidized ubiquinone-2 (Q-2) and then measured the kinetic responses of these two blocks to changes in Q-2 redox state as well as the flux control coefficients and the cytochrome content. We found that adult rats exhibited significantly higher state 3 respiratory rates with increased kinetic response of the substrate oxidation pathway to the mitochondrial membrane potential, slightly decreased activity of the phosphorylating system, increased kinetic responsesof both Q-2 reducers and oxidizers to Q-2 redox state, and increased cytochrome content. Our results indicate that important changes in thehepatic mitochondrial respiratory system occur in the transition fromweaning to adulthood in rats. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 05:37:35