Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IN-VITRO AND IN-VIVO DRUG-INTERACTIONS INVOLVING HUMAN CYP3A
Autore:
THUMMEL KE; WILKINSON GR;
Indirizzi:
UNIV WASHINGTON,DEPT PHARMACEUT SEATTLE WA 98195 VANDERBILT UNIV,DEPT PHARMACOL NASHVILLE TN 37232
Titolo Testata:
Annual review of pharmacology and toxicology
, volume: 38, anno: 1998,
pagine: 389 - 430
SICI:
0362-1642(1998)38:<389:IAIDIH>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-MICROSOMES; ERYTHROMYCIN BREATH TEST; HUMAN CYTOCHROME-P450 3A4; CYCLOSPORINE-A OXIDASE; REUPTAKE-INHIBITOR ANTIDEPRESSANTS; SYSTEMIC ANTIMYCOTICS KETOCONAZOLE; DEXTROMETHORPHAN N-DEMETHYLATION; METABOLIC-INTERMEDIATE COMPLEX; 1'-HYDROXY MIDAZOLAM FORMATION; KIDNEY-TRANSPLANT RECIPIENTS;
Keywords:
DRUG METABOLISM; FIRST-PASS METABOLISM; ENZYME INHIBITION; ENZYME INDUCTION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
278
Recensione:
Indirizzi per estratti:
Citazione:
K.E. Thummel e G.R. Wilkinson, "IN-VITRO AND IN-VIVO DRUG-INTERACTIONS INVOLVING HUMAN CYP3A", Annual review of pharmacology and toxicology, 38, 1998, pp. 389-430

Abstract

Cytochrome P4503A (CYP3A) is importantly involved in the metabolism of many chemically diverse drugs administered to humans. Moreover, its localization in high amounts both in the small intestinal epithelium and liver makes it a major contributor to presystemic elimination following oral drug administration. Drug interactions involving enzyme inhibition or induction are common following the coadministration of two or more CYP3A substrates. Studies using in vitro preparations are useful in identifying such potential interactions and possibly permitting extrapolation of in vitro findings to the likely in vivo situation. Even if accurate quantitative predictions cannot be made, several classesof drugs can be expected to result in a drug interaction based on clinical experience. In many instances, the extent of such drug interactions is sufficiently pronounced to contraindicate the therapeutic use of the involved drugs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:31:06