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Titolo:
CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2
Autore:
VANE JR; BAKHLE YS; BOTTING RM;
Indirizzi:
QUEEN MARY & WESTFIELD COLL,ST BARTHOLOMEWS & ROYAL LONDON SCH MED & DENT LONDON EC1M 6BQ ENGLAND
Titolo Testata:
Annual review of pharmacology and toxicology
, volume: 38, anno: 1998,
pagine: 97 - 120
SICI:
0362-1642(1998)38:<97:CAC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROSTAGLANDIN-G/H SYNTHASE-1; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; ENDOPEROXIDE-H SYNTHASE-1; HUMAN FETAL MEMBRANES; ASPIRIN-LIKE DRUGS; MESSENGER-RNA; SELECTIVE-INHIBITION; INDUCIBLE CYCLOOXYGENASE; ALZHEIMERS-DISEASE; COLORECTAL-CANCER;
Keywords:
PROSTAGLANDINS; NONSTEROIDAL ANTIINFLAMMATORY DRUGS; SELECTIVE INHIBITORS; INFLAMMATION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
127
Recensione:
Indirizzi per estratti:
Citazione:
J.R. Vane et al., "CYCLOOXYGENASE-1 AND CYCLOOXYGENASE-2", Annual review of pharmacology and toxicology, 38, 1998, pp. 97-120

Abstract

Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid. In 1991, several laboratories identified a product from a second gene with COX activity and called it COX-2. However, COX-2 was inducible, and the inducing stimuli included pro-inflammatory cytokines and growth factors, implying a role for COX-2 in both inflammation and control of cell growth. The two isoforms of COX are almost identical instructure but have important differences in substrate and inhibitor selectivity and in their intracellular locations. Protective PGs, whichpreserve the integrity of the stomach lining and maintain normal renal function in a compromised kidney, are synthesized by COX-1. In addition to the induction of COX-2 in inflammatory lesions, it is present constitutively in the brain and spinal cord, where it may be involved in nerve transmission, particularly that for pain and fever. PGs made by COX-2 are also important in ovulation and in the birth process. The discovery of COX-2 has made possible the design of drugs that reduce inflammation without removing the protective PGs in the stomach and kidney made by COX-1. These highly selective COX-2 inhibitors may not only be anti-inflammatory but may also be active in colon cancer and Alzheimer's disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:38:37