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Titolo:
PLASMA AND MUCOSAL FATTY-ACID PATTERN IN COLECTOMIZED ULCERATIVE-COLITIS PATIENTS
Autore:
ESTEVE M; NAVARRO E; KLAASSEN J; ABADLACRUZ A; GONZALEZHUIX F; CABRE E; RAMOS E; CONDOM E; FERNANDEZBANARES F; PASTOR C; HUMBERT P; MARTIRAGUE J; GASSULL MA;
Indirizzi:
HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL,CARRETERA CANYET S-N BADALONA 08916 SPAIN HOSP UNIV GERMANS TRIAS & PUJOL,DEPT GASTROENTEROL BADALONA 08916 SPAIN HOSP SANT LLORENC,DEPT GASTROENTEROL BARCELONA SPAIN HOSP JOSEP TRUETA,DEPT GASTROENTEROL GIRONA CATALONIA SPAIN CIUTAT SANIT UNIV BELLVITGE,DEPT PATHOL LHOSPITALET LLOBR SPAIN CIUTAT SANIT UNIV BELLVITGE,DEPT SURG LHOSPITALET LLOBR SPAIN
Titolo Testata:
Digestive diseases and sciences
fascicolo: 5, volume: 43, anno: 1998,
pagine: 1071 - 1078
SICI:
0163-2116(1998)43:5<1071:PAMFPI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY BOWEL-DISEASE; POUCH-ANAL ANASTOMOSIS; ACTIVE CROHNS-DISEASE; COLONIC MUCOSA; FISH-OIL; ILEAL; PROSTAGLANDINS; PHOSPHOLIPIDS; METABOLISM; LIPIDS;
Keywords:
ULCERATIVE COLITIS; PROCTOCOLECTOMY; ILEAL POUCH ANAL ANASTOMOSIS; POUCHITIS; FATTY ACIDS; FISH OIL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M. Esteve et al., "PLASMA AND MUCOSAL FATTY-ACID PATTERN IN COLECTOMIZED ULCERATIVE-COLITIS PATIENTS", Digestive diseases and sciences, 43(5), 1998, pp. 1071-1078

Abstract

Patients with inflammatory towel disease (IBD) have increased plasma n3 polyunsaturated fatty acids (PUFAs), which in ulcerative colitis (UC) patients persists six months after colectomy, suggesting a primary abnormality in fatty acid (FA) metabolism in IBD, This finding needed to be confirmed in a larger series of UC long-term colectomized patients. We aimed to assess the plasma FA pattern in UC colectomized patients with either Brooke's ileostomy (UC-BI) or ileal pouch anal anastomosis (UC-IPAA) and the mucosal FA pattern in the ileal reservoir of theUC-IPAA patients. Plasma FAs were assessed in 63 UC colectomized patients (31 with BI and 32 with IPAA) and 30 controls. In 26 UC-IPAA (8 with pouchitis and 18 without pouchitis) and in 13 healthy controls gutmucosal FAs were also investigated, FAs were detected by capillary column gas-liquid chromatography. Increased levels of saturated fatty acids (SFAs) and decreased percentages of monounsaturated fatty acids (MUFAs) were observed in both groups of patients. There were no changes in plasma n3 and n6 PUFAs. The mucosal FA pattern of the ileal reservoir consisted of increased long-chain PUFAs, specially n6 PUFA, and a decrease of their essential precursors. High percentages of SFAs and low percentages of MUFAs were also seen. The plasma FA profile previously described in IBD is not observed long term after colectomy in UC, suggesting that it is related with the presence of inflamed intestine. High concentrations of SFAs and decreased percentages of MUFAs might represent early events in disturbed FA metabolism in IBD. The changes inFAs of the ileal reservoir, which closely resemble those found in human and experimental IBD, probably represent a common pattern of intestinal inflammation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:20:48