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Titolo:
ULTRARAPID DRUG-METABOLISM - PCR-BASED DETECTION OF CYP2D6 GENE DUPLICATION
Autore:
STEIJNS LSW; VANDERWEIDE J;
Indirizzi:
PSYCHIAT HOSP VELDWIJK,DEPT CLIN CHEM,POB 1000 NL-3850 BA ERMELO NETHERLANDS PSYCHIAT HOSP VELDWIJK,DEPT CLIN CHEM NL-3850 BA ERMELO NETHERLANDS
Titolo Testata:
Clinical chemistry
fascicolo: 5, volume: 44, anno: 1998,
pagine: 914 - 917
SICI:
0009-9147(1998)44:5<914:UD-PDO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYTOCHROME-P450 CYP2D6; SWEDISH POPULATION; POOR METABOLIZERS; DEBRISOQUINE; HYDROXYLATION; POLYMORPHISM; SPARTEINE; PHENOTYPE; ALLELES; IDENTIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
L.S.W. Steijns e J. Vanderweide, "ULTRARAPID DRUG-METABOLISM - PCR-BASED DETECTION OF CYP2D6 GENE DUPLICATION", Clinical chemistry, 44(5), 1998, pp. 914-917

Abstract

The enzyme debrisoquine 4-hydroxylase (CYP2D6), which metabolizes many widely used drugs, is highly polymorphic. The activity of the enzymeranges between subjects from ultrafast to a complete absence. Therefore, metabolic capacity varies, producing intersubject differences in therapeutic efficacy and side effects at standard recommended doses. Upto 7% of Caucasians may demonstrate ultrarapid drug metabolism (UM) because of inherited alleles with multiplicate functional CYP2D6 genes,causing an increased amount of enzyme to be expressed. Identificationof UM subjects is of potential clinical importance for adjustment of doses in drug therapy, as well as to avoid misidentification of noncompliance. In our study, we tested recently designed PCR assays for the detection of the UM genotype. We found a 3.5% prevalence of UMs carrying duplicate active CYP2D6 genes in a population consisting of 202 psychiatric patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/01/20 alle ore 12:29:04