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Titolo:
EFFECT OF BUTANEDIONE MONOXIME ON THE CONTRACTILITY OF GUINEA-PIG ILEUM AND ON THE ELECTROPHYSIOLOGICAL ACTIVITY OF MYENTERIC S-TYPE NEURONS
Autore:
LIZARRAGA I; ALFARO MJ; GOICOECHEA C; LOPEZ F; MARTIN MI;
Indirizzi:
UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN UNIV COMPLUTENSE MADRID,FAC MED,DEPT FARMACOL E-28040 MADRID SPAIN
Titolo Testata:
Neuroscience letters
fascicolo: 2, volume: 246, anno: 1998,
pagine: 105 - 108
SICI:
0304-3940(1998)246:2<105:EOBMOT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
2,3-BUTANEDIONE MONOXIME; POTASSIUM CONDUCTANCE; MUSCLE-FIBERS; ACTIVATION; PLEXUS; CHANNEL; HEART; BDM;
Keywords:
BUTANEDIONE MONOXIME; GUINEA PIG ILEUM; NEURONAL ELECTROPHYSIOLOGICAL RECORDING; S-TYPE NEURON; MYENTERIC PLEXUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
I. Lizarraga et al., "EFFECT OF BUTANEDIONE MONOXIME ON THE CONTRACTILITY OF GUINEA-PIG ILEUM AND ON THE ELECTROPHYSIOLOGICAL ACTIVITY OF MYENTERIC S-TYPE NEURONS", Neuroscience letters, 246(2), 1998, pp. 105-108

Abstract

2,3-Butanedione monoxime (BDM) has demonstrated protective effects onisolated cardiac tissues, and on smooth muscle but its mechanism of action is not fully understood. To simultaneously study the effect of BDM on muscle contractility and on neuronal activity, the effect of BDMwas tested in the contractile force of myenteric plexus-longitudinal muscle strips and in electrophysiological activity of myenteric S-typeneurones of guinea pig ileum. BDM reduces, in a dose-dependent manner, the force of the spontaneous motility and the contractions induced by acetylcholine, bethanechol and electrical stimulation. The same BDM concentrations depolarize the neuronal membrane and reduce the rate ofevoked firing. The effect of BDM can be attributed to a direct effecton the smooth muscle and to modifications of the neuronal activity. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:53:12