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Titolo:
A METAANALYSIS AND TRANSMISSION DISEQUILIBRIUM STUDY OF ASSOCIATION BETWEEN THE DOPAMINE D3 RECEPTOR GENE AND SCHIZOPHRENIA
Autore:
WILLIAMS J; SPURLOCK G; HOLMANS P; MANT R; MURPHY K; JONES L; CARDNO A; ASHERSON P; BLACKWOOD D; MUIR W; MESZAROS K; ASCHAUER H; MALLET J; LAURENT C; PEKKARINEN P; SEPPALA J; STEFANIS CN; PAPADIMITRIOU GN; MACCIARDI F; VERGA M; PATO C; AZEVEDO H; CROCQ MA; GURLING H; KALSI G; CURTIS D; MCGUFFIN P; OWEN MJ;
Indirizzi:
UNIV WALES COLL MED,DEPT PSYCHOL MED,HEATH PK CARDIFF CF4 4XN S GLAM WALES UNIV WALES COLL MED,INST MED GENET CARDIFF CF4 4XN S GLAM WALES INST OPHTHALMOL LONDON ENGLAND MOORFIELDS EYE HOSP,DEPT CLIN OPHTHALMOL LONDON EC1V 2PD ENGLAND INST PSYCHIAT LONDON ENGLAND UNIV EDINBURGH,ROYAL EDINBURGH HOSP,DEPT PSYCHIAT EDINBURGH EH10 5HF MIDLOTHIAN SCOTLAND UNIV VIENNA,HOSP PSYCHIAT,DEPT GEN PSYCHIAT A-1090 VIENNA AUSTRIA HOP LA PITIE SALPETRIERE,CNRS,LGN,LAB GENET MOL NEUROTRANSMISS & PROCNEURODEGENERA F-75651 PARIS 13 FRANCE NATL PUBL HLTH INST,DEPT HUMAN MOL GENET SF-00300 HELSINKI FINLAND NATL PUBL HLTH INST,DEPT MENTAL HLTH SF-00300 HELSINKI FINLAND UNIV ATHENS,EGINIT HOSP,SCH MED,DEPT PSYCHIAT GR-11528 ATHENS GREECE UNIV MILAN,SCH MED,IST SCI SAN RAFFAELE,DEPT NEUROSCI I-20127 MILAN ITALY UNIV COIMBRA,CTR NEUROSCI P-3000 COIMBRA PORTUGAL FDN APPL NEUROSCI RES PSYCHIAT F-66250 ROUFFACH FRANCE UNIV COLL LONDON,SCH MED,WINDEYER INST MED SCI,DEPT PSYCHIAT & BEHAV SCI LONDON W1N 8AA ENGLAND
Titolo Testata:
Molecular psychiatry
fascicolo: 2, volume: 3, anno: 1998,
pagine: 141 - 149
SICI:
1359-4184(1998)3:2<141:AMATDS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; LINKAGE DISEQUILIBRIUM; FAMILY HISTORY; RAT-BRAIN; POLYMORPHISM; HOMOZYGOSITY; SYSTEM; LOCUS; RELIABILITY; EXPRESSION;
Keywords:
D3 RECEPTOR GENE; METAANALYSIS; TDT; SCHIZOPHRENIA; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
62
Recensione:
Indirizzi per estratti:
Citazione:
J. Williams et al., "A METAANALYSIS AND TRANSMISSION DISEQUILIBRIUM STUDY OF ASSOCIATION BETWEEN THE DOPAMINE D3 RECEPTOR GENE AND SCHIZOPHRENIA", Molecular psychiatry, 3(2), 1998, pp. 141-149

Abstract

We performed a meta-analysis of over 30 case-control studies of association between schizophrenia and a bi-allelic, BalI polymorphism in exon 1 of the dopamine D3 receptor gene. We observed a significant excess of both forms of homozygote in patients (P = 0.0009, odds ratio (OR)= 1.21, 95% Confidence Interval (CI) = 1.07-1.35) in the combined sample of 5351 individuals. No significant heterogeneity was detected between samples and the effects did not appear to be the product of publishing bias. In addition we undertook an independent, family-based association study of this polymorphism in 57 parent/proband trios, taken from unrelated European multiplex families segregating schizophrenia. Atransmission disequilibrium test (TDT) showed a significant excess ofhomozygotes in schizophrenic patients (P = 0.004, odds ratio (OR)= 2.7, 95% CI = 1.35-5.86). Although no significant allelic association was observed, a significant association was detected with the 1-1 genotype alone (P = 0.02, OR = 2.32, 95% CI = 1.13-4.99). In addition when the results of the family-based association study were included in the meta-analysis, the homozygosity effect increased in significance (P = 0.0002, OR = 1.23, 95% CI = 1.09-1.38). The results of the meta-analysis and family-based association study provide independent support for a relationship between schizophrenia and homozygosity at the BalI polymorphism of the D3 receptor gene, or between a locus in linkage disequilibrium with it.

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Documento generato il 05/07/20 alle ore 03:57:54