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Titolo:
CARDIOVASCULAR STRESS-RESPONSE AND CORONARY-ARTERY DISEASE - EVIDENCEOF AN ADVERSE POSTMENOPAUSAL EFFECT IN WOMEN
Autore:
MERZ CNB; KOP W; KRANTZ DS; HELMERS KF; BERMAN DS; ROZANSKI A;
Indirizzi:
CEDARS SINAI MED CTR,PREVENT & REHABIL CARDIAC CTR,CEDARS SINAI RES INST,DEPT MED,DIV CARDIOL LOS ANGELES CA 90048 UNIV CALIF LOS ANGELES,SCH MED,DEPT MED LOS ANGELES CA 90024 UNIFORMED SERV UNIV HLTH SCI,DEPT MED & CLIN PSYCHOL BETHESDA MD 20814 YORK UNIV TORONTO ON M3J 2R7 CANADA COLUMBIA UNIV COLL PHYS & SURG,ST LUKES ROOSEVELT HOSP CTR NEW YORK NY 10032 CEDARS SINAI MED CTR,CEDARS SINAI RES INST,DEPT NUCL MED LOS ANGELES CA 90048
Titolo Testata:
The American heart journal
fascicolo: 5, volume: 135, anno: 1998,
parte:, 1
pagine: 881 - 887
SICI:
0002-8703(1998)135:5<881:CSACD->2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED MYOCARDIAL-ISCHEMIA; NEURO-ENDOCRINE RESPONSES; MENTAL STRESS; BLOOD-PRESSURE; SEX-DIFFERENCES; INFARCTION; REACTIVITY; ESTROGEN; ATHEROSCLEROSIS; GENDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
C.N.B. Merz et al., "CARDIOVASCULAR STRESS-RESPONSE AND CORONARY-ARTERY DISEASE - EVIDENCEOF AN ADVERSE POSTMENOPAUSAL EFFECT IN WOMEN", The American heart journal, 135(5), 1998, pp. 881-887

Abstract

Objectives To test the hypothesis that postmenopausal women demonstrate greater vascular instability, measured by enhanced cardiovascular stress responses during mental stress, compared with men and premenopausal women. Background Recent data suggest that estrogen plays a role in regulating vascular tone. The possible consequences of estrogen deficiency during menopause on systemic vascular reactivity is largely unexplored. Methods One hundred subjects (84 men and 16 women) underwent mental stress testing with radionuclide ventriculography. Study subjects included 19 normal volunteers, 23 control subjects with chest pain syndromes or hypertension but without coronary artery disease, and 58 coronary artery disease subjects. The subjects performed a series of three mental stress tasks, during which hemodynamic data and radionuclide ventriculograms were obtained. Results Overall, women demonstrated greater hemodynamic responses during mental stress measured by changesin heart rate, systolic and diastolic blood pressure, and double product compared with those of men (all p < 0.05). Women with coronary artery disease demonstrated greater heart rate, diastolic blood pressure,and double product stress responses than their male counterparts (allp < 0.05). Women of postmenopausal age demonstrated significantly greater systolic blood pressure reactivity than men or premenopausal women (p < 0.05). Conclusions Women of postmenopausal age have greater cardiovascular responses to stress than men or premenopausal women. Thesefindings suggest an additional mechanism by which estrogen deficiencyconveys a poor prognosis in female patients with coronary artery disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:33:18