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Titolo:
PLASMA BRAIN NATRIURETIC PEPTIDE AS A BIOCHEMICAL MARKER OF HIGH LEFT-VENTRICULAR END-DIASTOLIC PRESSURE IN PATIENTS WITH SYMPTOMATIC LEFT-VENTRICULAR DYSFUNCTION
Autore:
MAEDA K; TSUTAMOTO T; WADA A; HISANAGA T; KINOSHITA M;
Indirizzi:
SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 5202192 JAPAN SHIGA UNIV MED SCI,DEPT INTERNAL MED 1 OTSU SHIGA 5202192 JAPAN
Titolo Testata:
The American heart journal
fascicolo: 5, volume: 135, anno: 1998,
parte:, 1
pagine: 825 - 832
SICI:
0002-8703(1998)135:5<825:PBNPAA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CONGESTIVE-HEART-FAILURE; ACUTE MYOCARDIAL-INFARCTION; CULTURED RAT ATRIAL; LONG-TERM SURVIVAL; PROGNOSTIC VALUE; SECRETION; NOREPINEPHRINE; ENDOTHELIN-1; ACTIVATION; HORMONE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
K. Maeda et al., "PLASMA BRAIN NATRIURETIC PEPTIDE AS A BIOCHEMICAL MARKER OF HIGH LEFT-VENTRICULAR END-DIASTOLIC PRESSURE IN PATIENTS WITH SYMPTOMATIC LEFT-VENTRICULAR DYSFUNCTION", The American heart journal, 135(5), 1998, pp. 825-832

Abstract

Background Plasma atrial natriuretic peptide (ANP), mainly from the atrium, brain natriuretic peptide (BNP), mainly from the ventricle, norepinephrine (NE), and endothelin-1 (ET-1) levels are increased with the severity of congestive heart Failure (CHF). Although a close correlation between the left ventricular end-diastolic pressure (LVEDP) and plasma ANP in patients with left ventricular dysfunction has been reported, it is not yet known which cardiac natriuretic peptide is a betterpredictor of high LVEDP in patients with CHF. Methods To investigate the biochemical predictors of the high LVEDP in patients with left ventricular dysfunction, we measured plasma ANP, BNP, NE, and ET-1 levelsand the hemodynamic parameters in 72 patients with symptomatic left ventricular dysfunction. Stepwise multivariate regression analyses werealso used to determine whether the plasma levels of ANP, BNP, NE, andET-1 could predict high LVEDP. Results Although significant positive correlations were found among the plasma levels of ANP, BNP, ET-1, andNE and the LVEDP, only BNP (p = 0.0001) was an independent and significant predictor of high LVEDP in patients with CHF. In all eight patients with severe CHF measured for hemodynamics before and after the treatments, the plasma BNP levels decreased in association with the decrease of LVEDP, whereas other factors increased in some patients despitethe decrease of LVEDP. Conclusions These findings suggest that plasmaBNP is superior to ANP as a predictor of high LVEDP in patients with symptomatic left ventricular dysfunction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:06:07