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Titolo:
THE PLATELET SEROTONIN TRANSPORTER IN PRIMARY HEADACHES
Autore:
BENDTSEN L; MELLERUP ET;
Indirizzi:
UNIV COPENHAGEN,GLOSTRUP HOSP,DEPT NEUROL DK-2600 GLOSTRUP DENMARK UNIV COPENHAGEN,RIGSHOSP,LAB NEUROPSYCHIAT DK-2100 COPENHAGEN O DENMARK
Titolo Testata:
European journal of neurology
fascicolo: 3, volume: 5, anno: 1998,
pagine: 277 - 282
SICI:
1351-5101(1998)5:3<277:TPSTIP>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TENSION-TYPE HEADACHE; H-3 IMIPRAMINE BINDING; PRESSURE PAIN THRESHOLDS; PAROXETINE BINDING; DEPRESSED-PATIENTS; MIGRAINE PATIENTS; 5-HYDROXYTRYPTAMINE; AMITRIPTYLINE; SITES;
Keywords:
PLATELET TRANSPORTER; PLATELET UPTAKE; SEROTONIN; TENSION-TYPE HEADACHE; MIGRAINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
L. Bendtsen e E.T. Mellerup, "THE PLATELET SEROTONIN TRANSPORTER IN PRIMARY HEADACHES", European journal of neurology, 5(3), 1998, pp. 277-282

Abstract

Serotonin (5-HT) plays a major role in the pathophysiology of primaryheadaches. The presynaptic 5-HT uptake mechanism, which is important for the regulation of 5-HT levels in the neuronal synapses, can be examined indirectly by measuring the number of 5-HT transporters in membranes from platelets. The aim of the present study was to investigate the platelet 5-HT transport system in patients with primary headache disorders. B-max, an index of the number of platelet 5-HT transporters, was measured in 40 patients with chronic tension-type headache, in 30 patients with migraine without aura, and in 40 healthy controls using a binding analysis with tritiated paroxetine as the ligand. The B-max was 664 (589-846) (median (quartiles)) fmol/mg protein in patients with tension-type headache and 662 (534-781) fmol/mg protein in healthy controls, P = 0.40. The B-max was 675 (558-747) fmol/mg protein in patients with migraine, which was not significantly different from the B-max in controls, P = 0.94. In conclusion, the present results indicate that the number of platelet 5-HT transporters is normal in patients with chronic tension-type headache and in patients with migraine withoutaura. (C) 1998 Lippincott-Raven Publishers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/20 alle ore 21:03:41