Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EFFECTS OF GH AND IGF-I ADMINISTRATION ON GHRH AND SOMATOSTATIN MESSENGER-RNA LEVELS .2. A STUDY IN THE INFANT RAT
Autore:
GRILLI R; GHIGO MC; TORSELLO A; GUIDI M; LUONI M; LOCATELLI V; MULLER EE;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL,FAC MED,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,DEPT PHARMACOL,FAC MED I-20129 MILAN ITALY
Titolo Testata:
Journal of endocrinological investigation
fascicolo: 3, volume: 20, anno: 1997,
pagine: 151 - 154
SICI:
0391-4097(1997)20:3<151:EOGAIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-RELEASING FACTOR; GROWTH-HORMONE; HYPOPHYSECTOMIZED RATS; NEGATIVE FEEDBACK; STIMULATES GROWTH; SOMATIC GROWTH; PITUITARY;
Keywords:
GH; IGF-I; SOMATOSTATIN; GHRH; FEEDBACK; INFANT; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
R. Grilli et al., "EFFECTS OF GH AND IGF-I ADMINISTRATION ON GHRH AND SOMATOSTATIN MESSENGER-RNA LEVELS .2. A STUDY IN THE INFANT RAT", Journal of endocrinological investigation, 20(3), 1997, pp. 151-154

Abstract

It is generally accepted that growth hormone influences its own secretion by modulating the activity of GHRH and SRIF neurons. To investigate if GH feedback mechanisms are already operating in the early postnatal life of the rat, we have studied in IO-day-old pups the effects ofrhGH and rhIGF-I administration on GHRH and somatostatin mRNA levels,The same experiment was also performed in pups passively immunized with an anti-GHRH antiserum from the day of birth. The latter animal model had been previously characterized for presenting reduced levels of circulating GH and IGF-I. In control pups, neither rhGH (250 mu g/kg,b.i.d., sc) nor rhIGF-I (150 mu g/kg, b.i.d., sc) administration induced significant changes of GHRH and SRIF gene expression. The passive immunization against GHRH induced per se a trend toward an increase and a reduction of GHRH and SRIF mRNA levels, respectively. Also in these rats the treatment for 3 days with rhGH and rhIGF-I did not further modify the GHRH and SRIF mRNA levels. Based on these results, we conclude that in the 10-day-old rat GH feedback mechanisms are poorly operative, though a direct ultra-short loop mechanism involving the GHRH and SRIF systems seems already operating. (C) 1997, Editrice Kurtis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/10/20 alle ore 03:46:37