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Titolo:
EFFECTS OF GH AND IGF-I ADMINISTRATION ON GHRH AND SOMATOSTATIN MESSENGER-RNA LEVELS .1. A STUDY ON AD-LIBITUM FED AND STARVED ADULT MALE-RATS
Autore:
GHIGO MC; TORSELLO A; GRILLI R; LUONI M; GUIDI M; CELLA SG; LOCATELLI V; MULLER EE;
Indirizzi:
UNIV MILAN,DEPT PHARMACOL,VIA VANVITELLI 32 I-20129 MILAN ITALY UNIV MILAN,DEPT PHARMACOL I-20129 MILAN ITALY
Titolo Testata:
Journal of endocrinological investigation
fascicolo: 3, volume: 20, anno: 1997,
pagine: 144 - 150
SICI:
0391-4097(1997)20:3<144:EOGAIA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH FACTOR-I; HORMONE-RELEASING-FACTOR; ANTERIOR-PITUITARY CELLS; SOMATOMEDIN-C; NEGATIVE FEEDBACK; FOOD-DEPRIVATION; INSULIN; BRAIN; HYPOTHALAMUS; RECEPTORS;
Keywords:
GH; IGF-I; SOMATOSTATIN; GHRH; FEEDBACK; RAT; STARVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
M.C. Ghigo et al., "EFFECTS OF GH AND IGF-I ADMINISTRATION ON GHRH AND SOMATOSTATIN MESSENGER-RNA LEVELS .1. A STUDY ON AD-LIBITUM FED AND STARVED ADULT MALE-RATS", Journal of endocrinological investigation, 20(3), 1997, pp. 144-150

Abstract

The individual role played by GH and IGF-I in the regulation of hypothalamic GHRH and SRIF gene expression is still object of debate. We have investigated the effect of exogenously administered recombinant hGH(rhGH) and recombinant hIGF-I (rhIGF-I) in ad libitum fed control andstarved rats, the latter an animal model which is characterized by low circulating levels of endogenous GH and IGF-I. Adult male rats were fed ad libitum (C) or food-deprived (S) for 72 hours; rats in either Cor S groups were treated with systemic administration of rhGH and rhIGF-I for 3 days. GHRH, SRIF and GH mRNA levels were evaluated by Northern and slot blot hybridization. Administration of rhGH (250 mu g/kg/twice daily, sc) induced a significant inhibition of GHRH and a significant stimulation of SRIF mRNA levels in C rats; GH treatment was, however, ineffective on both neuropeptide mRNA levels in the S group. Continuous infusion of rhIGF-I (300 mu g/kg/day, sc) induced a significantincrease of SRIF levels in both C and S rats but did not modify GHRH mRNA levels in either group. In the pituitary, GH mRNA levels followeda pattern very similar to that of GHRH. These results provide evidence for a direct role of GH in the inhibition of GHRH mRNA levels; IGF-Iappears more involved in the direct stimulation of SRIF mRNA levels. (C) 1997, Editrice Kurtis.

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Documento generato il 01/10/20 alle ore 04:37:15