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Titolo:
DIFFERENTIAL REGULATION OF HEPATIC ARTERIAL AND PORTAL VENOUS VASCULAR-RESISTANCE BY NITRIC-OXIDE AND CARBON-MONOXIDE IN RATS
Autore:
PANNEN BHJ; BAUER M;
Indirizzi:
UNIV FREIBURG,ANAESTHESIOL KLIN,DEPT ANESTHESIOL & CRIT CARE MED,HUGSTETTER STR 55 D-79106 FREIBURG GERMANY UNIV SAARLAND,DEPT ANESTHESIOL & CRIT CARE MED D-66421 HOMBURG GERMANY
Titolo Testata:
Life sciences
fascicolo: 22, volume: 62, anno: 1998,
pagine: 2025 - 2033
SICI:
0024-3205(1998)62:22<2025:DROHAA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEME OXYGENASE; ENDOGENOUS MODULATOR; BLOOD-FLOW; LIVER; MECHANISMS; RELAXATION; EXPRESSION; SYNTHASE; SHOCK; TONE;
Keywords:
NITRIC OXIDE; CARBON MONOXIDE; HEPATIC ARTERIAL CIRCULATION; PORTAL VENOUS VASCULAR RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
B.H.J. Pannen e M. Bauer, "DIFFERENTIAL REGULATION OF HEPATIC ARTERIAL AND PORTAL VENOUS VASCULAR-RESISTANCE BY NITRIC-OXIDE AND CARBON-MONOXIDE IN RATS", Life sciences, 62(22), 1998, pp. 2025-2033

Abstract

Nitric oxide (NO), a gaseous mediator that accounts for the biological activity of endothelium-derived relaxing factor, has been shown to play an important role in the reduction of basal vascular tone in multiple vascular beds, including the hepatic circulation. On the other hand, recent studies have provided first evidence that endogenously generated carbon monoxide (CO) may exert vasodilatory effects in the hepatic portal vein and within sinusoids. Thus, we defined the differential role of NO and CO in the regulation of vascular resistance in the two inflows to the liver in the normal rat in vivo. Male Sprague-Dawley rats were anesthetized with pentobarbitaI sodium and surgically instrumented in order to study the change in hepatic arterial (R-ha) and portal venous vascular resistance (R-pv) in response to intravenous bolus administration of either the NO-synthase inhibitor N-omega-nitro-L-arginine methyl ester (l- NAME) (1 mg/kg, n = 7 animals) or of tin protoporphyrin-IX (SnPP-IX) (50 mu mol/kg), a specific inhibitor of the GO-generating enzyme heme oxygenase (n = 8 animals). While L-NAME caused a substantial increase in R-ha, R-pv increased only slightly under theseconditions. In sharp contrast, SnPP-IX did not affect R-ha but causeda profound increase in R-pv. In conclusion, R-ha and R-pv are differentially regulated by NO and CO in the normal rat liver in vivo, i.e., NO serves as a potent vasodilator in the hepatic arterial circulation,but exerts only a minor vasodilatory effect in the portal venous vascular bed. In contrast, while there is no intrinsic CO-mediated vasodilation in the hepatic artery, CO acts to maintain portal venous vascular tone in a relaxed state.

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Documento generato il 04/12/20 alle ore 19:58:26