Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DOES PATTERN ELECTRORETINOGRAM SPATIAL TUNING ALTERATION IN PARKINSONS-DISEASE DEPEND ON MOTOR DISTURBANCES OR RETINAL DOPAMINERGIC LOSS
Autore:
PEPPE A; STANZIONE P; PIERANTOZZI M; SEMPRINI R; BASSI A; SANTILLI AM; FORMISANO R; PICCOLINO M; BERNARDI G;
Indirizzi:
IRCCS CLIN,VIA ARDEATINA 306 I-00179 ROME ITALY UNIV ROMA TOR VERGATA,NEUROL CLIN ROME ITALY UNIV FERRARA,IST FISIOL GEN FERRARA ITALY
Titolo Testata:
Electroencephalography and clinical neurophysiology
fascicolo: 4, volume: 106, anno: 1998,
pagine: 374 - 382
SICI:
0013-4694(1998)106:4<374:DPESTA>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VISUAL-EVOKED-POTENTIALS; GAP JUNCTION PERMEABILITY; CONTRAST SENSITIVITY; VERTEBRATE RETINA; HORIZONTAL CELLS; OPTIC-NERVE; DYSFUNCTION; TURTLE; ERG; MODULATION;
Keywords:
PERG; PARKINSONS DISEASE; RETINA; DOPAMINE; EXTRAPYRAMIDAL SYMPTOMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A. Peppe et al., "DOES PATTERN ELECTRORETINOGRAM SPATIAL TUNING ALTERATION IN PARKINSONS-DISEASE DEPEND ON MOTOR DISTURBANCES OR RETINAL DOPAMINERGIC LOSS", Electroencephalography and clinical neurophysiology, 106(4), 1998, pp. 374-382

Abstract

Systemic decrease of dopaminergic cells, such as in Parkinson's disease may produce visual alterations in humans. Zn order to show possiblepattern electroretinogram (PERG) spatial tuning function (STE) alterations due to impaired dopaminergic transmission in humans, we studied a group of Parkinson's disease patients before and during treatment with the dopamine precursor, levodopa, and compared theirperformances with those of an age-matched control group. Moreover, in order to exclude the possible involvement of motor disabilities to produce PERG alterations, we also investigated PERC responses in post-traumatic parkinsonian patients who exhibited motor abnormalities as a consequence of focal lesions of basal ganglia, in the absence of systemic dopaminergic degeneration. Our results showed a clear decrease of PERG responses inParkinson's disease patients particularly at medium spatial frequencyrange (2.7-4.0 cycles/degree) with a substantial preservation of responses at low frequencies. Levodopa therapy reversed these alterations in Parkinson's disease patients, resulting in the recovery of a normaltuning function shape. In contrast to Parkinson's disease, the tuningfunction appeared to be preserved in post-traumatic parkinsonian patients. Our results clearly establish a relationship between retinal alteration in PD patients and dopaminergic retinal function. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 07:31:54