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Titolo:
THE DOPAMINE D-3 RECEPTOR (DRD3) SER(9)GLY POLYMORPHISM AND SCHIZOPHRENIA - A HAPLOTYPE RELATIVE RISK STUDY AND ASSOCIATION WITH CLOZAPINE RESPONSE
Autore:
MALHOTRA AK; GOLDMAN D; BUCHANAN RW; ROONEY W; CLIFTON A; KOSMIDIS MH; BREIER A; PICKAR D;
Indirizzi:
NIMH,EXPT THERAPEUT BRANCH,NIH,10 CTR DR,BLDG 10,ROOM 4N212 BETHESDA MD 20892 NIAAA,NEUROGENET LAB,NIH ROCKVILLE MD 20852 UNIV MARYLAND,MARYLAND PSYCHIAT RES CTR,DEPT PSYCHIAT CATONSVILLE MD 21228
Titolo Testata:
Molecular psychiatry
fascicolo: 1, volume: 3, anno: 1998,
pagine: 72 - 75
SICI:
1359-4184(1998)3:1<72:TDDR(S>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
D3 RECEPTOR; GENE; HOMOZYGOSITY;
Keywords:
POLYMORPHISM; DOPAMINE 3 RECEPTOR; SCHIZOPHRENIA; CLOZAPINE; GENETICS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
A.K. Malhotra et al., "THE DOPAMINE D-3 RECEPTOR (DRD3) SER(9)GLY POLYMORPHISM AND SCHIZOPHRENIA - A HAPLOTYPE RELATIVE RISK STUDY AND ASSOCIATION WITH CLOZAPINE RESPONSE", Molecular psychiatry, 3(1), 1998, pp. 72-75

Abstract

Several lines of evidence suggest that the dopamine D-3 receptor is involved in the pathophysiology of schizophrenia.(1-3) The D-3 receptorgene (DRD3) contains a polymorphism resulting in a serine-glycine substitution in the N-terminus of the receptor.(4) Shaikh and colleagues(5) have reported a significant association between the DRD3 Ser, allele and the Ser(9)/Ser(9) genotype with schizophrenia in 133 Caucasians. In a meta-analysis of previous studies, Ser(9) and the Ser(9)/Ser(9) genotype were found to be significantly associated with schizophrenia,although these investigators could not confirm reports(6,7) of excesshomozygosity at this locus in schizophrenia. These authors also report that, in an unblinded study, the Ser(9)/Ser(9) genotype was more frequent in patients who did not respond to clozapine, These data represent the most comprehensive examination of DRD3 Ser(9)Gly in schizophrenia to date, We have therefore determined DRD3 Ser(9)Gly genotypes in 58 patients with schizophrenia and in their parents. Moreover, we have genotyped 68 schizophrenics participating in double-blind clozapine trials, We do not find that Ser(9) is preferentially transmitted in schizophrenia, cannot confirm excess DRD3 homozygosity in schizophrenia, and do not replicate the association between DRD3 and clozapine response. These data suggest that allelic variation in DRD3 may not play a role in the pathophysiology of schizophrenia or in clozapine response.

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Documento generato il 31/03/20 alle ore 22:42:05