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Titolo:
FEMORAL NONUNION FRACTURE TREATED WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 IN A DOG
Autore:
ITOH T; MOCHIZUKI M; FUDA K; NISHIMURA R; MATSUNAGA S; KADOSAWA T; SASAKI N;
Indirizzi:
UNIV TOKYO,GRAD SCH AGR & LIFE SCI,DIV VET MED SCI,LAB VET SURG TOKYO1130032 JAPAN HOKKAIDO UNIV,GRAD SCH VET MED,DEPT VET CLIN SCI,LAB VET SURG SAPPOROHOKKAIDO 060081 JAPAN
Titolo Testata:
Journal of veterinary medical science
fascicolo: 4, volume: 60, anno: 1998,
pagine: 535 - 538
SICI:
0916-7250(1998)60:4<535:FNFTWR>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FAMILY; MATRIX;
Keywords:
BMP; CANINE; NONUNION FRACTURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
T. Itoh et al., "FEMORAL NONUNION FRACTURE TREATED WITH RECOMBINANT HUMAN BONE MORPHOGENETIC PROTEIN-2 IN A DOG", Journal of veterinary medical science, 60(4), 1998, pp. 535-538

Abstract

This is the first report on successful treatment of spontaneous nonunion fracture of a dog by use of recombinant human bone morphogenetic protein-2 (rhBMP-2). A 4-year-old Pomeranian dog with a 2-year history of femoral nonunion fracture was treated with implantation of rhBMP-2. The dog had received surgical correction twice prior to the admissionbut radiography of the affected limb revealed a typical figure of nonunion fracture. Glossly, the fractured ends were sclerotic and the area between the ends was filled with fibrous tissue. After debridement the femoral shaft was fixed by an 8-hole plate. rhBMP-2 at a total doseof 256 mu g was implanted with a synthetic carrier into the 8-mm defect formed by the debridement. Callus formation responding to rhBMP-2 was radiographically observed at 2 weeks after implantation and the defect reached radiographic union by 8 weeks after implantation. The plate was removed at 9 months after implantation. Any complications were not observed for 5 months after removal of the plate.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:03:58