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Titolo:
SMALL DRUG SAMPLE FABRICATION OF CONTROLLED-RELEASE POLYMERS USING THE MICROEXTRUSION METHOD
Autore:
HAIKCREGUER KL; DUNBAR GL; SABEL BA; SCHROEDER U;
Indirizzi:
OTTO VON GUERICKE UNIV,INST MED PHYSIOL,FAC MED,LEIPZIGER STR 44 D-39120 MAGDEBURG GERMANY OTTO VON GUERICKE UNIV,INST MED PHYSIOL,FAC MED D-39120 MAGDEBURG GERMANY CENT MICHIGAN UNIV,DEPT PSYCHOL MT PLEASANT MI 48859
Titolo Testata:
Journal of neuroscience methods
fascicolo: 1, volume: 80, anno: 1998,
pagine: 37 - 40
SICI:
0165-0270(1998)80:1<37:SDSFOC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
RATS; ANTAGONISTS; DOPAMINE; DELIVERY; INVIVO; MATRIX;
Keywords:
POLYVINYL ACETATE POLYMER; CONTROLLED RELEASE; ALPHA-METHYL-P-TYROSINE; DIAZEPAM; PHENCYCLIDINE; QUINOLINIC ACID;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K.L. Haikcreguer et al., "SMALL DRUG SAMPLE FABRICATION OF CONTROLLED-RELEASE POLYMERS USING THE MICROEXTRUSION METHOD", Journal of neuroscience methods, 80(1), 1998, pp. 37-40

Abstract

Ethylene vinylacetate polymer (EVA) has been used for many years to fabricate controlled-release polymeric implant devices with which drugsof high or low molecular weight compounds could be delivered with zero-order kinetics. However, because the known fabrication methods such as solvent evaporation, casting and possible shrinkage are not sufficiently controllable we have now developed the microextrusion method with which even small amount of clinically important and expensive drugs can be incorporated into EVA with high reproducibility. We show here that devices produced by the microextrusion method allows for a controlled delivery of several neurotoxic and neurotherapeutic compounds suchas alpha-methyl-p-tyrosine, diazepam, quinolinic acid, and phencyclidine. Each substance is slowly released from the polymer, as evidenced by spectrophotometric data, for up to 120 days at daily rates varying from 18.4 mu g of phencyclidine to 97.6 mu g/day of diazepam. Thus, microextrusion is a valuable method for fabricating controlled-release polymers in which small amounts of scarce drugs can be incorporated. Another advantage of the current procedure is that polymers can be fabricated with very little amount of solvent. (C) 1998 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/21 alle ore 04:49:00