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Titolo:
INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN-KINASE PROMOTE NEURONAL SURVIVAL IN-VITRO
Autore:
HORSTMANN S; KAHLE PJ; BORASIO GD;
Indirizzi:
UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL,MARCHIONINISTR 15 D-81377 MUNICH GERMANY UNIV MUNICH,KLINIKUM GROSSHADERN,DEPT NEUROL D-81377 MUNICH GERMANY STANFORD UNIV,MED CTR,SCH MED,DEPT NEUROBIOL STANFORD CA 94305
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 52, anno: 1998,
pagine: 483 - 490
SICI:
0360-4012(1998)52:4<483:IOPMPP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; NERVOUS-SYSTEM; MAP KINASE; C-JUN; SB-203580; APOPTOSIS; INVITRO; PATHWAY; CREB;
Keywords:
APOPTOSIS; CHICK EMBRYONIC NEURONS; JUN KINASE; RIBOSOMAL S6 KINASE; PYRIDINYL IMIDAZOLE COMPOUNDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
S. Horstmann et al., "INHIBITORS OF P38 MITOGEN-ACTIVATED PROTEIN-KINASE PROMOTE NEURONAL SURVIVAL IN-VITRO", Journal of neuroscience research, 52(4), 1998, pp. 483-490

Abstract

Mammalian mitogen-activated protein kinases include the extracellularsignal-regulated protein kinase, the c-Jun amino-terminal kinase, andthe p38 subgroups. Sustained activation of Jun kinase and p38 have been shown to precede apoptosis of PC12 pheochromocytoma cells induced by withdrawal of trophic factors. To investigate the possible role of p38 in neuronal apoptosis, we tested the effect of two selective p38 inhibitors, the pyridinyl imidazole compounds SB203580 and SB202190, on different populations of chick embryonic neurons in vitro. Both substances promoted the in vitro survival of sensory, sympathetic, ciliary and motor neurons in a dose-dependent fashion. When assayed in nerve growth factor-stimulated PC12 cells, SB203580 pretreatment inhibited theactivation of both ribosomal S6 kinases-1 and -2 with the same IC50 (approximately 30 mu M) that inhibited apoptosis in primary neurons. Thus, p38 inhibitor-sensitive pathways may be involved in apoptosis of neurotrophic factor-deprived primary neurons, and in activation of ribosomal S6 kinases. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:56:26