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Titolo:
GENDER DIFFERENCES IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS DEVELOP DURING THE INDUCTION OF THE IMMUNE-RESPONSE TO ENCEPHALITOGENIC PEPTIDES
Autore:
BEBO BF; SCHUSTER JC; VANDENBARK AA; OFFNER H;
Indirizzi:
DEPT VET AFFAIRS,3710 SW US VET HOSP RD PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT NEUROL PORTLAND OR 97201 OREGON HLTH SCI UNIV,DEPT MOL MICROBIOL & IMMUNOL PORTLAND OR 97201
Titolo Testata:
Journal of neuroscience research
fascicolo: 4, volume: 52, anno: 1998,
pagine: 420 - 426
SICI:
0360-4012(1998)52:4<420:GDIEAE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS; MULTIPLE-SCLEROSIS; SEX-HORMONES; LEWIS RAT; SJL MICE; MACROPHAGES; PREGNANCY; TESTOSTERONE; SUPPRESSION; ESTRADIOL;
Keywords:
MULTIPLE SCLEROSIS; PROTEOLIPID PROTEIN; SEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B.F. Bebo et al., "GENDER DIFFERENCES IN EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS DEVELOP DURING THE INDUCTION OF THE IMMUNE-RESPONSE TO ENCEPHALITOGENIC PEPTIDES", Journal of neuroscience research, 52(4), 1998, pp. 420-426

Abstract

Multiple sclerosis (MS) strikes women more often than men, Gender differences in experimental autoimmune encephalomyelitis (EAE) parallel those seen in MS. We utilized the adoptive transfer model of EAE to determine the role of gender on the induction and effector phases of disease. PLP 139-151-sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However, there were no gender differences in the frequency of PLP 139-151-specific T cells. PLP 139-151-specific female T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences theimmune response primarily during the induction phase. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:54:52