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Titolo:
ROLE OF MEDIAL SMOOTH-MUSCLE CELL-FUNCTION IN ANTITHROMBOGENICITY OF VEIN GRAFTS
Autore:
YATSUYANAGI E; SASAJIMA T; GOH K; INABA M; KUBO Y;
Indirizzi:
ASAHIKAWA MED COLL,DEPT SURG 1,NISIKAGURA 4-5 ASAHIKAWA HOKKAIDO 078 JAPAN
Titolo Testata:
European journal of vascular and endovascular surgery
fascicolo: 4, volume: 15, anno: 1998,
pagine: 350 - 356
SICI:
1078-5884(1998)15:4<350:ROMSCI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN SAPHENOUS-VEIN; PROSTACYCLIN PRODUCTION; ENDOTHELIAL DENUDATION; INTEGRITY; PROSTAGLANDINS; PRESERVATION; REPERFUSION; DISTENSION; ARTERIES; RELEASE;
Keywords:
AUTOGENOUS VEIN GRAFT; PROSTACYCLIN; SMOOTH MUSCLE CELL; ENDOTHELIAL CELL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
E. Yatsuyanagi et al., "ROLE OF MEDIAL SMOOTH-MUSCLE CELL-FUNCTION IN ANTITHROMBOGENICITY OF VEIN GRAFTS", European journal of vascular and endovascular surgery, 15(4), 1998, pp. 350-356

Abstract

Objectives: To determine the significance of prostaglandin I-2 (PGI(2)) production by medial smooth muscle cells (SMCs), we assessed PGI(2)production from denuded vein grafts and their antithrombogenicity. Materials and Methods: A total of 30 dogs were divided into two groups: in group I, 14 dogs (27 veins, 188 segments) were used to assay PGI(2)production, which was measured as 6-keto-PGF(1 alpha). In group II, 16 dogs were used for an implantation study and the thrombus-free surface (TFS) score was calculated 24h after implantation. Both groups contained the following subgroups: subgroup A, freshly harvested veins; subgroup B, endothelial denuded veins; subgroup C, veins frozen. and cryopreserved; subgroup D, veins treated with protease. Results: Values of 6-keto-PGF(1 alpha) (pg/mg/min) for basal and stimulated states in subgroup I-A through I-D were 58.0 +/- 8.9 and 530.6 +/- 74.7, 26.3 +/-4.7 and 82.3 +/- 11.4, 17.9 +/- 1.3 and 39.4 +/- 3.3, and 13.3 +/- 1.8 and 32.2 +/- 6.2, respectively. The PGI(2) production in subgroup I-A were significantly higher than those in the other three subgroups (p<0.01 for basal and stimulated), while the production in subgroup I-B was also significantly higher than those in the remaining two (p<0.05 for basal and stimulated). The TFS scores in subgroup II-A through II-D were 98 +/- 2% 90 +/- 2%, 38 +/- 5%, and 15 +/- 7% respectively, showing significantly superior antithrombogenicity in subgroup II-B, as well as in II-A, when compared with the remaining two (p=0.014).Conclusion: The amount of PGI(2) generated by the medial SMCs may be sufficient for maintaining the antithrombogenicity of the endothelial denuded AVGs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:44:39