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Titolo:
SUPPRESSION OF PROTEIN-KINASE-C AND NUCLEAR ONCOGENE EXPRESSION AS POSSIBLE MOLECULAR MECHANISMS OF CANCER CHEMOPREVENTION BY APIGENIN AND CURCUMIN
Autore:
LIN JK; CHEN YC; HUANG YT; LINSHIAU SY;
Indirizzi:
NATL TAIWAN UNIV,COLL MED,INST BIOCHEM,CANC RES LAB TAIPEI TAIWAN NATL TAIWAN UNIV,COLL MED,INST TOXICOL & PHARMACOL TAIPEI 10018 TAIWAN
Titolo Testata:
Journal of cellular biochemistry
, , anno: 1997, supplemento:, 28-29
pagine: 39 - 48
SICI:
0730-2312(1997):<39:SOPANO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURALLY-OCCURRING FLAVONOIDS; MOUSE FIBROBLAST CELLS; TUMOR INITIATION; DIETARY CURCUMIN; NIH3T3 CELLS; PROMOTION; INHIBITION; ACID; INDOLE-3-CARBINOL; BENZO)A>PYRENE;
Keywords:
APIGENIN; CURCUMIN; KAEMPFEROL; GENISTEIN; PKC; PTK; C-JUN, C-FOS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Lin et al., "SUPPRESSION OF PROTEIN-KINASE-C AND NUCLEAR ONCOGENE EXPRESSION AS POSSIBLE MOLECULAR MECHANISMS OF CANCER CHEMOPREVENTION BY APIGENIN AND CURCUMIN", Journal of cellular biochemistry, 1997, pp. 39-48

Abstract

Apigenin, a less-toxic and non-mutagenic flavonoic, suppressed -O-tetradecanoyl-phorbol-13-acetate-(TPA)-mediated tumor promotion of mouse skin. TPA had the ability to activate protein kinase C (PKC) and induced nuclear proto-oncogene expression. Our study indicates that apigenin inhibited PKC by competing with adenosine triphosphate (ATP). Apigenin also reduced the level of PPA-stimulated phosphorylation of cellular proteins and inhibited TPA-induced c-jun and c-fos expression. Curcumin, a dietary pigment phytopolyphenol, is also a potent inhibitor of tumor promotion induced by TPA in mouse skin. When mouse fibroblast cells were treated with TPA alone, PKC translocated from the cytosolic fraction to the particulate fraction. Treatment with 15 or 20 mu M curcumin for 15 min inhibited TPA-induced PKC activity in the particulate fraction by 26-60%. Curcumin also inhibited PKC activity in vitro by competing with phosphatidylserine. Curcumin (10 mu M) suppressed the expression of c-jun in TPA-treated cells. Fifteen flavonoids were examined for their effects on morphological changes in soft agar and cellular growth in v-H-ras transformed NIH3T3 cells. The results demonstratedthat only apigenin, kaempferol, and genistein exhibited the revertingeffect on the transformed morphology of these cells. Based on these findings, it is suggested that the suppression of PKC activity and nuclear oncogene expression might contribute to the molecular mechanisms of inhibition of TPA-induced tumor promotion by apigenin and curcumin. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:04:44