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Titolo:
UMBILICAL DOPPLER VELOCIMETRY IN FETUSES WITH TRISOMY-18 AT 10-18 WEEKS GESTATION
Autore:
MARTINEZ JM; ANTOLIN E; BORRELL A; PUERTO B; CASALS E; OJUEL J; FORTUNY A;
Indirizzi:
AVDA REPUBL ARGENTINA 263,ATICO 2A BARCELONA 08023 SPAIN HOSP CLIN BARCELONA,DEPT OBSTET & GYNAECOL,PRENATAL DIAGNOSIS UNIT BARCELONA SPAIN HOSP CLIN BARCELONA,SERV BIOCHEM BARCELONA SPAIN UNIV BARCELONA,BIOSTAT UNIT BARCELONA SPAIN
Titolo Testata:
Prenatal diagnosis
fascicolo: 4, volume: 17, anno: 1997,
pagine: 319 - 322
SICI:
0197-3851(1997)17:4<319:UDVIFW>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
2ND-TRIMESTER FETUSES; ARTERY; 1ST-TRIMESTER; VELOCITY; FEATURES; RISK;
Keywords:
DOPPLER VELOCIMETRY; TRISOMY 18; PRENATAL DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Martinez et al., "UMBILICAL DOPPLER VELOCIMETRY IN FETUSES WITH TRISOMY-18 AT 10-18 WEEKS GESTATION", Prenatal diagnosis, 17(4), 1997, pp. 319-322

Abstract

The aim of our study was to obtain measurements of the umbilical artery pulsatility index (PI) in pregnancies before invasive procedures for prenatal diagnosis, in order to investigate its potential prognosticvalue in predicting trisomy 18. We performed a prospective study including 1785 consecutive women from 10 to 18 weeks with singleton pregnancies undergoing chorionic villus sampling (n=559) or genetic amniocentesis (n=1226) in our unit. Doppler measurements were performed transvaginally (tenth to 13th week of gestation) or transabdominally (14th to 18th week of gestation) immediately before the invasive procedure. In 7 out of 10 fetuses subsequently diagnosed as trisomy 18, the PI wasabove the 95th centile, providing a detection rate of 70 per cent, a specificity of 95.1 per cent, a positive predictive value of 7.7 per cent, and a negative predictive value of 99.8 per cent. When the 90th percentile was assayed as a cut-off, the efficacy of PI as a marker of trisomy 18 yielded a sensitivity of 90 per cent and a specificity of 90.4 per cent, with a positive predictive value of 5.2 per cent and a negative predictive value of 99.9 per cent. We suggest that although the use of a single PI measurement for screening purposes needs to be confirmed by further investigation, trisomy 18 fetuses show an abnormal increase in umbilical PI in the first half of pregnancy, and its relation to the early onset of fetal growth retardation needs to be furtherexplored. (C) 1997 by John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:37:59