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Titolo:
A ROLE FOR CH-CENTER-DOT-CENTER-DOT-CENTER-DOT-O INTERACTIONS IN PROTEIN-DNA RECOGNITION
Autore:
MANDELGUTFREUND Y; MARGALIT H; JERNIGAN RL; ZHURKIN VB;
Indirizzi:
NCI,LAB EXPT & COMPUTAT BIOL,NIH,BLDG 12B,RM B116,MSC 5677,12 SOUTH DR BETHESDA MD 20892 HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT MOL GENET & BIOTECHNOL IL-91120 JERUSALEM ISRAEL
Titolo Testata:
Journal of Molecular Biology
fascicolo: 5, volume: 277, anno: 1998,
pagine: 1129 - 1140
SICI:
0022-2836(1998)277:5<1129:ARFCII>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
REPRESSOR-OPERATOR COMPLEX; CRYSTAL-STRUCTURE; HYDROGEN-BONDS; NUCLEIC-ACIDS; 2.5-ANGSTROM RESOLUTION; BINDING DOMAIN; MINOR-GROOVE; CRYSTALLOGRAPHIC EVIDENCE; B/HLH/Z DOMAIN; ATOMIC CHARGES;
Keywords:
PROTEIN-DNA RECOGNITION; HYDROGEN BONDS; CH-CENTER-DOT-CENTER-DOT-CENTER-DOT-O INTERACTIONS; ELECTROSTATICS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
70
Recensione:
Indirizzi per estratti:
Citazione:
Y. Mandelgutfreund et al., "A ROLE FOR CH-CENTER-DOT-CENTER-DOT-CENTER-DOT-O INTERACTIONS IN PROTEIN-DNA RECOGNITION", Journal of Molecular Biology, 277(5), 1998, pp. 1129-1140

Abstract

The concept of CH ... O hydrogen bonds has recently gained much interest, with a number of reports indicating the significance of these non-classical hydrogen bonds in stabilizing nucleic acid and protein structures. Here, we analyze the CH ... O interactions in the protein-DNA interface, based on 43 crystal structures of protein-DNA complexes. Surprisingly, we find that the number of close intermolecular CH ... O contacts involving the thymine methyl group and position C5 of cytosineis comparable to the number of protein-DNA hydrogen bonds involving nitrogen and oxygen atoms as donors and acceptors. A comprehensive analysis of the geometries of these close contacts shows that they are similar to other CH ... O interactions found in proteins and small molecules, as well as to classical NH ... O hydrogen bonds. Thus, we suggestthat C5 of cytosine and C5-Met of thymine form relatively weak CH ... O hydrogen bonds with Asp, Asn, Glu, Gin, Ser, and Thr, contributing to the specificity of recognition. Including these interactions, in addition to the classical protein-DNA hydrogen bonds, enables the extraction of simple structural principles for amino acid-base recognition consistent with electrostatic considerations. (C) 1998 Academic Press Limited.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 16:02:57