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Titolo:
EXPRESSION PATTERNS OF THE HIV TYPE-1 CORECEPTORS CCR5 AND CXCR4 ON CD4(-CELLS AND MONOCYTES FROM CORD AND ADULT-BLOOD() T)
Autore:
MO HM; MONARD S; POLLACK H; IP J; ROCHFORD G; WU LJ; HOXIE J; BORKOWSKY W; HO DD; MOORE JP;
Indirizzi:
AARON DIAMOND AIDS RES CTR,455 FIRST AVE NEW YORK NY 10021 ROCKEFELLER UNIV,AARON DIAMOND AIDS RES CTR NEW YORK NY 10016 NYU,SCH MED,DEPT PEDIAT NEW YORK NY 10016 LEUKOSITE INC CAMBRIDGE MA 02142 UNIV PENN,DIV HEMATOL ONCOL PHILADELPHIA PA 19104
Titolo Testata:
AIDS research and human retroviruses
fascicolo: 7, volume: 14, anno: 1998,
pagine: 607 - 617
SICI:
0889-2229(1998)14:7<607:EPOTHT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; AGE-RELATED-CHANGES; VIRAL PHENOTYPE; DISEASE PROGRESSION; LYMPHOCYTE SUBSETS; PERIPHERAL-BLOOD; INFECTION; RECEPTOR; TRANSMISSION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Mo et al., "EXPRESSION PATTERNS OF THE HIV TYPE-1 CORECEPTORS CCR5 AND CXCR4 ON CD4(-CELLS AND MONOCYTES FROM CORD AND ADULT-BLOOD() T)", AIDS research and human retroviruses, 14(7), 1998, pp. 607-617

Abstract

We have measured the surface expression of the HIV-1 coreceptors CCR5and CXCR4 on CD4(+) T cells and monocytes from cord and adult blood. The expression of CCR5 was largely restricted to the memory (CD45RA(low)) subset, whereas CXCR4 was expressed on both memory and naive (CD45RA(high)) T cells. The paucity of memory CD4(+) T cells in cord blood means that CCR5-positive cells are relatively uncommon, so the overallextent of CCR5 expression was reduced in cord blood, compared with adult blood, IL-2 activation of CD4(+) T cells from both cord and adult bloods caused a substantial increase in CCR5 expression, but moderately decreased CXCR4 expression. PHA stimulation increased CCR5 expression slightly, but only on naive cells. Monocytes expressed both CCR5 andCXCR4 at levels that differed little between cord and adult blood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 15:48:39