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Titolo:
GENETIC-POLYMORPHISM OF DRUG-METABOLIZING-ENZYMES - NEW MUTATIONS IN CYP2D6 AND CYP2A6 GENES IN JAPANESE
Autore:
YOKOI T; KAMATAKI T;
Indirizzi:
HOKKAIDO UNIV,FAC PHARMACEUT SCI,DIV DRUG METAB,KITA 12 SAPPORO HOKKAIDO 060 JAPAN KANAZAWA UNIV,FAC PHARMACEUT SCI,DIV DRUG METAB KANAZAWA ISHIKAWA 920JAPAN
Titolo Testata:
Pharmaceutical research
fascicolo: 4, volume: 15, anno: 1998,
pagine: 517 - 524
SICI:
0724-8741(1998)15:4<517:GOD-NM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LIVER-MICROSOMES; COUMARIN 7-HYDROXYLASE ACTIVITY; HUMAN CYTOCHROME P4502D6; POOR METABOLIZERS; CHINESE SUBJECTS; C-OXIDATION; DEBRISOQUINE; IDENTIFICATION; POPULATION; NICOTINE;
Keywords:
GENETIC POLYMORPHISM; PHENOTYPE; DRUG METABOLISM; GENOTYPE; CYTOCHROME P450; PHARMACOGENETICS; CLINICAL PHARMACOLOGY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
63
Recensione:
Indirizzi per estratti:
Citazione:
T. Yokoi e T. Kamataki, "GENETIC-POLYMORPHISM OF DRUG-METABOLIZING-ENZYMES - NEW MUTATIONS IN CYP2D6 AND CYP2A6 GENES IN JAPANESE", Pharmaceutical research, 15(4), 1998, pp. 517-524

Abstract

Genetic polymorphism of drug metabolizing enzymes, particularly cytochrome P450 (CYP), is an important cause of adverse drug reactions. Multiple gene mutations in CYP have been shown to be phenotype. The occurrence of genetic polymorphism has been seen in genes for CYP1A1, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A5. This review discusses the molecular mechanism of two genetic polymorphisms, debrisoquine/sparteine (CYP2D6) coumarin (CYP2A6) polymorphisms. In addition, elucidation of gene mutations of CYP2D6 and CYP2A6 in Japanese will be discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 19:22:00