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Titolo:
ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN GLIOBLASTOMA-MULTIFORMECELL-LINE
Autore:
BAKIR A; GEZEN F; YILDIZ O; AYHAN A; KAHRAMAN S; KRUSE CA; VARELLAGARCIA M; YILDIZ F; KUBAR A;
Indirizzi:
GULHANE SCH MED,DEPT PHARMACOL TR-06078 ANKARA TURKEY GULHANE SCH MED,DEPT PHARMACOL TR-06078 ANKARA TURKEY GULHANE SCH MED,DEPT NEUROSURG ANKARA TURKEY GULHANE SCH MED,DEPT VIROL ANKARA TURKEY HACETTEPE SCH MED,DEPT PATHOL ANKARA TURKEY HACETTEPE SCH MED,DEPT RADIAT ONCOL ANKARA TURKEY UNIV COLORADO,HLTH SCI CTR,DEPT IMMUNOL,CANC CTR CYTOGENET CORE DENVER CO 00000
Titolo Testata:
Cancer genetics and cytogenetics
fascicolo: 1, volume: 103, anno: 1998,
pagine: 46 - 51
SICI:
0165-4608(1998)103:1<46:EACOAH>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIBRILLARY ACIDIC PROTEIN; HUMAN BRAIN-TUMORS; HUMAN GLIOMAS; DELETION; CHROMOSOME-10; MUTATIONS; GENES; P53; HETEROZYGOSITY; HETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
A. Bakir et al., "ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN GLIOBLASTOMA-MULTIFORMECELL-LINE", Cancer genetics and cytogenetics, 103(1), 1998, pp. 46-51

Abstract

Cell lines provide a useful system for further understanding the biology of glioblastoma multiforme. In this study, a new glioblastoma multiforme cell line, GATAGM-96 (Gulhane Askeri Tip Akademisi-GlioblastomaMultiforme-96), was established from a tumor specimen removed from an80-year-old male patient who underwent surgery for intracranial tumor. Morphologic examination, immunocytochemical staining, growth kinetics, and karyotypic characteristics of this cell line were studied. The cytoskeleton wets positive for neuron-specific enolase, vimentin, and neurofilament, and it was negative for glial fibrillary acidic protein, S-100 protein, p53 protein, epidermal growth factor, and transforming growth factor cc. Growth kinetic studies demonstrated an approximatepopulation doubling time of 38 to 42 h and a colony forming efficiency of 83.3%. The karyotype of the cells demonstrated it as hyperdiploid, with a large subpopulation of polyploid cells. There were numerous structural and numerical chromosome aberrations; most of them were present as clonal events. The phenotypic and chromosomal features detailedon the GATAGM-96 cell line should make it a useful addition to the cell lines currently available for in vitro and in vivo studies of glioblastoma multiforme. (C) Elsevier Science Inc., 1998.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:15:29