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Titolo:
PROPOFOL DOES NOT AMELIORATE CEREBRAL VENOUS OXYHEMOGLOBIN DESATURATION DURING HYPOTHERMIC CARDIOPULMONARY BYPASS
Autore:
SOUTER MJ; ANDREWS PJD; ALSTON RP;
Indirizzi:
SO GEN HOSP,INST NEUROL SCI,1345 GOVAN RD GLASGOW G51 4TF LANARK SCOTLAND ROYAL EDINBURGH & ASSOCIATED HOSP,DEPT ANAESTHET EDINBURGH MIDLOTHIANSCOTLAND WESTERN GEN HOSP EDINBURGH EH4 2XU MIDLOTHIAN SCOTLAND
Titolo Testata:
Anesthesia and analgesia
fascicolo: 5, volume: 86, anno: 1998,
pagine: 926 - 931
SICI:
0003-2999(1998)86:5<926:PDNACV>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-SATURATION; HEAD-INJURY; BLOOD-FLOW; PROTECTION; ANESTHESIA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
M.J. Souter et al., "PROPOFOL DOES NOT AMELIORATE CEREBRAL VENOUS OXYHEMOGLOBIN DESATURATION DURING HYPOTHERMIC CARDIOPULMONARY BYPASS", Anesthesia and analgesia, 86(5), 1998, pp. 926-931

Abstract

Reductions in cerebral venous oxyhemoglobin saturation (Sjo(2)) occurduring the rewarming phase of hypothermic cardiopulmonary bypass (CPB). We prospectively investigated the effects of propofol on these reductions in Sjo(2) (Sjo(2) <50%). Fiberoptic jugular bulb catheters wereinserted in 30 patients undergoing coronary artery bypass grafting. Patients were randomly allocated to a test or control group. Test grouppatients (n = 15) received a propofol IV infusion titrated to electroencephalographic burst suppression during CPB. No significant differences in Sjo(2) <50% were found between the groups either by blood sampling and bench oximetry or fiberoptic oximetry. The arteriovenous difference in lactate concentration became negative in 59 of 120 samples. Propofol was associated with an increased incidence of hypotension (mean arterial pressure <50 mm Hg) (P = 0.023), an increased requirement for vasoconstrictor therapy (P = 0.025), and increases in the lactate oxygen index (P < 0.01). Propofol, when administered in doses that produce electroencephalographic burst suppression, does not attenuate the frequency or extent of reductions of Sjo(2) below 50% during rewarmingfrom hypothermic CPB. However, it is associated with arterial hypotension and an increase in cerebral anaerobic metabolism. Implications: Reductions in cerebral venous oxyhemoglobin saturation during the rewarming phase of cardiopulmonary bypass may be related to brain injury. When administered in doses sufficient to produce electroencephalographic burst suppression, propofol did not attenuate the frequency or extent of such reductions in cerebral venous oxyhemoglobin saturation.

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Documento generato il 18/09/20 alle ore 15:10:04