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Titolo:
CAGA-POSITIVE HELICOBACTER-PYLORI POPULATIONS IN CHINA AND THE NETHERLANDS ARE DISTINCT
Autore:
VANDERENDE A; PAN ZJ; BART A; VANDERHULST RWM; FELLER M; XIAO SD; TYTGAT GNJ; DANKERT J;
Indirizzi:
UNIV AMSTERDAM,DEPT MED MICROBIOL,ACAD MED CTR,POB 22700 NL-1100 DE AMSTERDAM NETHERLANDS UNIV AMSTERDAM,DEPT GASTROENTEROL,ACAD MED CTR NL-1100 DE AMSTERDAM NETHERLANDS SHANGHAI MED UNIV 2,SHANGHAI INST DIGEST DIS SHANGHAI PEOPLES R CHINA
Titolo Testata:
Infection and immunity
fascicolo: 5, volume: 66, anno: 1998,
pagine: 1822 - 1826
SICI:
0019-9567(1998)66:5<1822:CHPICA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PEPTIC-ULCER DISEASE; VACUOLATING CYTOTOXIN; NUCLEOTIDE-SEQUENCES; DUODENAL-ULCER; METRONIDAZOLE; DIVERSITY; INFECTION; GASTRITIS; EVOLUTION; ANTIGEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
A. Vanderende et al., "CAGA-POSITIVE HELICOBACTER-PYLORI POPULATIONS IN CHINA AND THE NETHERLANDS ARE DISTINCT", Infection and immunity, 66(5), 1998, pp. 1822-1826

Abstract

The aim of this research was to study whether and to what extent Chinese cagA-positive Helicobacter pylori isolates differ from those in The Netherlands, Analysis of random amplified polymorphic DNA (RAPD)-PCR-assessed DNA fingerprints of chromosomal DNA of 24 cagA-positive H. pylori isolates from Dutch (Iz = 12) and Chinese (n = 10) patients yielded the absence of clustering. Based on comparison of the sequence of a 243-nucleotide part of cagA, the Dutch (group I) and Chinese (group II) H. pylori isolates formed two separate branches with high confidence limits in the phylogenetic tree, These two clusters were not observed when the sequence of a 240-bp part of glmM was used in the comparison. The number of nonsynonymous substitutions was much higher in cagA than in glmM, indicating positive selection. The average levels of divergence of cagA at the nucleotide and protein levels between group I and II isolates were found to be high, 13.3 and 17.9%, respectively. Possibly, the pathogenicity island (PAI) that has been integrated into the chromosome of the ancestor of H. pylori now circulating in China contained a different cagA than the PAI that has been Integrated into the chromosome of the ancestor of H. pylori now circulating in The Netherlands. We conclude that in China and The Netherlands, two distinct cagA-positive H. pylori populations are circulating.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 04:05:27