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Titolo:
STAPHYLOKINASE MUTANTS - NEW THROMBOLYTIC AGENTS
Autore:
LEBRAZI J; ELALAMY I; HELFT G; SAMAMA MM;
Indirizzi:
HOP HOTEL DIEU,SERV HEMATOL BIOL,1 PL PARVIS NOTRE DAME F-75181 PARIS04 FRANCE HOP HOTEL DIEU,SERV HEMATOL BIOL F-75181 PARIS 04 FRANCE
Titolo Testata:
Journal des maladies vasculaires
fascicolo: 2, volume: 23, anno: 1998,
pagine: 92 - 98
SICI:
0398-0499(1998)23:2<92:SM-NTA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
FRE
Soggetto:
RECOMBINANT STAPHYLOKINASE; MYOCARDIAL-INFARCTION; STAPHYLOCOCCUS-AUREUS; ESCHERICHIA-COLI; STREPTOKINASE; PLASMINOGEN; FIBRIN; GENE; ALPHA-2-ANTIPLASMIN; EXPRESSION;
Keywords:
STAPHYLOKINASE; THROMBOLYTIC AGENTS; ACUTE MYOCARDIAL INFARCTION; FIBRIN; IMMUNOGENICITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
J. Lebrazi et al., "STAPHYLOKINASE MUTANTS - NEW THROMBOLYTIC AGENTS", Journal des maladies vasculaires, 23(2), 1998, pp. 92-98

Abstract

Staphylokinase which is extracted from Staphylococci has been known for more than 40 years as a profibrinolytic compound. It has been obtained more recently by genetic engineering. Staphylokinase activates plasminogen into plasmin. It is a promising new thrombolytic agent for the treatment of acute myocardial infarction and thromboembolic disease in general. It is a fibrin specific thrombolytic agent which does not decrease plasma fibrinogen level in treated patients. However it is antigenic and the group of Louvain has made much effort to reduce its antigenicity without decreasing its thrombolytic activity. Mutants whitha reduced antigenic activity have been recently obtained. These new thrombolytic agents could be superior to currently used drugs. Staphylokinase mutants could have a better benefit/cost ratio than other thrombolytic agents.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:56:29